C₂₆H₃₀F₃N₅O₄

Base Information

• Chemical Name: C₂₆H₃₀F₃N₅O₄
• CAS No.: 1007374-45-9
• Molecular Formula: C₂₆H₃₀F₃N₅O₄
• Molecular Weight: 533.551
• Mol file: 1007374-45-9.mol

Synonyms:C₂₆H₃₀F₃N₅O₄

Chemical Property of C₂₆H₃₀F₃N₅O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₀F₃N₅O₄

There total 18 articles about C₂₆H₃₀F₃N₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H30ClF3N2O4 (1007374-44-8) → C26H30F3N5O4 (1007374-45-9)

Guidance literature:

With sodium azide; In water; acetone; Heating / reflux;

Reference yield:

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → C26H30F3N5O4 (1007374-45-9)

Guidance literature:

Multi-step reaction with 9 steps

1.1: N-iodo-succinimide; potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

2.1: P,P-dichlorophenylphosphine oxide / 136 °C

2.2: 0 - 20 °C / pH 6

3.1: potassium carbonate / dimethyl sulfoxide / 2 h / 100 °C

4.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 4.08 - 6.08 h / Heating / reflux

5.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; tert-butyl alcohol / 20 °C

6.1: sodium periodate / tetrahydrofuran; water / 6.08 h / 0 - 20 °C

7.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

8.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

9.1: sodium azide / water; acetone / Heating / reflux

With P,P-dichlorophenylphosphine oxide; sodium tetrahydroborate; sodium periodate; N-iodo-succinimide; osmium(VIII) oxide; thionyl chloride; sodium azide; potassium carbonate; 4-methylmorpholine N-oxide; N,N-dimethyl-formamide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

Reference yield:

2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine (887707-23-5) → C26H30F3N5O4 (1007374-45-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: P,P-dichlorophenylphosphine oxide / 136 °C

1.2: 0 - 20 °C / pH 6

2.1: potassium carbonate / dimethyl sulfoxide / 2 h / 100 °C

3.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 4.08 - 6.08 h / Heating / reflux

4.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; tert-butyl alcohol / 20 °C

5.1: sodium periodate / tetrahydrofuran; water / 6.08 h / 0 - 20 °C

6.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

7.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

8.1: sodium azide / water; acetone / Heating / reflux

With P,P-dichlorophenylphosphine oxide; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; thionyl chloride; sodium azide; potassium carbonate; 4-methylmorpholine N-oxide; N,N-dimethyl-formamide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; acetone; tert-butyl alcohol;

upstream raw materials:

C₂₆H₃₀ClF₃N₂O₄

3-(trifluoromethyl)pyridin-2-ol

2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine

2-chloro-5-iodo-3-(trifluoromethyl)pyridine

Refernces