1-{2-[methyl({3-[(methylamino)methyl]phenyl}carbonyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

Base Information

Chemical Name:1-{2-[methyl({3-[(methylamino)methyl]phenyl}carbonyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate
CAS No.:1246247-71-1
Molecular Formula:C₃₀H₃₆N₄O₃
Molecular Weight:500.641
Hs Code.:

Synonyms:1-{2-[methyl({3-[(methylamino)methyl]phenyl}carbonyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

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Chemical Property of 1-{2-[methyl({3-[(methylamino)methyl]phenyl}carbonyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

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Technology Process of 1-{2-[methyl({3-[(methylamino)methyl]phenyl}carbonyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

There total 2 articles about 1-{2-[methyl({3-[(methylamino)methyl]phenyl}carbonyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 909899-75-8
1-(2-{[(3-Formylphenyl)carbonyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

: 74-89-5
methylamine

: 1246247-71-1
1-{2-[methyl({3-[(methylamino)methyl]phenyl}carbonyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: 1-(2-{[(3-Formylphenyl)carbonyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate; methylamine; With sodium tris(acetoxy)borohydride; In methanol; at 20 ℃; for 16h; Inert atmosphere; Cooling with ice;

With sodium hydrogencarbonate; In methanol; water;

Reference yield:

: 743460-48-2
biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester

: 619-21-6
m-formylphenyl benzoic acid

: 1246247-71-1
1-{2-[methyl({3-[(methylamino)methyl]phenyl}carbonyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 16 h / 20 °C / Inert atmosphere; Cooling with ice

2: sodium tris(acetoxy)borohydride / methanol / 16 h / 20 °C / Inert atmosphere; Cooling with ice

With sodium tris(acetoxy)borohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;