1-(Imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine

Base Information

• Chemical Name: 1-(Imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine
• CAS No.: 2717-95-5
• Molecular Formula: C₁₀H₁₃N₃
• Molecular Weight: 175.233
• DSSTox Substance ID: DTXSID20569003
• Nikkaji Number: J1.977.073G
• Wikidata: Q82455694
• Mol file: 2717-95-5.mol

Synonyms:2717-95-5;3-[(dimethylamino)methyl]imidazo[1,2-a]pyridine;1-(Imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine;3-((dimethylamino)methyl)imidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridine-3-methanamine, N,N-dimethyl-;1-imidazo[1,2-a]pyridin-3-yl-N,N-dimethylmethanamine;SCHEMBL7230392;DTXSID20569003;MFCD06200768;AKOS006294463;SY289380;F18248

Chemical Property of 1-(Imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine

Chemical Property:

• Melting Point: 80-81 °C(Solv: ligroine (8032-32-4))
• PKA: 8.47±0.28(Predicted)
• PSA: 20.54000
• Density: 1.08±0.1 g/cm3(Predicted)
• LogP: 1.39590
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 175.110947427
• Heavy Atom Count: 13
• Complexity: 170

Purity/Quality:

99% ^*data from raw suppliers

3-[(DIMETHYLAMINO)METHYL]IMIDAZO[1,2-A]PYRIDINE 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CC1=CN=C2N1C=CC=C2

Technology Process of 1-(Imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine

There total 3 articles about 1-(Imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

imidazo[1,2-a]pyridine (274-76-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1-(imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine (2717-95-5)

Guidance literature:

With tert.-butylhydroperoxide; copper(II) bis(trifluoromethanesulfonate); In decane; at 90 ℃; for 12h;

DOI:10.1016/j.tetlet.2020.152581

Reference yield: 68.0%

imidazo[1,2-a]pyridine (274-76-0) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + N,N-dimethylammonium chloride (506-59-2) → 1-(imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine (2717-95-5)

Guidance literature:

In butan-1-ol; for 3h; Reflux;

DOI:10.1021/jm200388e

Reference yield:

→ 1-(imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine (2717-95-5)

Guidance literature:

Imido<1.2-a>pyridin, Dimethylamin, Formaldehyd, wss. Essigsaeure, 50grad, 2h;

DOI:10.1021/jo01018a071

upstream raw materials:

imidazo[1,2-a]pyridine

formaldehyd

N,N-dimethylammonium chloride

N,N-dimethyl-formamide

Downstream raw materials:

2-(imidazo[1,2-a]pyridin-3-yl)acetonitrile

imidazo[1,2-a]pyridine-3-carbaldehyde

2-(imidazo[1,2-a]pyridin-3-yl)ethylamine

(E)-N-hydroxy-3-(4-{[2-(imidazo[1,2-a]pyridin-3-yl)ethylamino]methyl}phenyl)acrylamide