N-(2-FLUOROPHENYL)-1,2-DIAMINOBENZENE

Base Information

• Chemical Name: N-(2-FLUOROPHENYL)-1,2-DIAMINOBENZENE
• CAS No.: 28898-03-5
• Molecular Formula: C12H11 F N2
• Molecular Weight: 202.231
• Hs Code.: 2921519090
• Mol file: 28898-03-5.mol

Synonyms:1,2-Benzenediamine,N-(2-fluorophenyl)- (9CI); o-Phenylenediamine, N-(o-fluorophenyl)- (8CI);N-(2-Fluorophenyl)benzene-1,2-diamine

Chemical Property of N-(2-FLUOROPHENYL)-1,2-DIAMINOBENZENE

Chemical Property:

• PSA: 38.05000
• LogP: 3.80570
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-2''-fluorodiphenylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-2''-fluorodiphenylamine is a useful intermediate for the synthesis of fluorophenazines.

Technology Process of N-(2-FLUOROPHENYL)-1,2-DIAMINOBENZENE

There total 5 articles about N-(2-FLUOROPHENYL)-1,2-DIAMINOBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(2-Fluorophenyl)-2-nitrobenzeneamine (28898-02-4) → N-(2-fluorophenyl)benzene-1,2-diamine (28898-03-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃; for 4h; under 760.051 Torr;

Reference yield:

2-Fluoroaniline (348-54-9) → N-(2-fluorophenyl)benzene-1,2-diamine (28898-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / KF / 20 h / 180 °C

2: 76 percent / K₂CO₃, Na₂S₂O₄ / ethanol; H₂O / 3 h / 23 °C

With potassium fluoride; sodium dithionite; potassium carbonate; In ethanol; water;

DOI:10.1002/ardp.19973301107

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → N-(2-fluorophenyl)benzene-1,2-diamine (28898-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / KF / 20 h / 180 °C

2: 76 percent / K₂CO₃, Na₂S₂O₄ / ethanol; H₂O / 3 h / 23 °C

With potassium fluoride; sodium dithionite; potassium carbonate; In ethanol; water;

DOI:10.1002/ardp.19973301107

upstream raw materials:

N-(2-Fluorophenyl)-2-nitrobenzeneamine

2-Fluoroaniline

ortho-nitrofluorobenzene

2-Chloronitrobenzene

Downstream raw materials:

2-(3,3-dimethylbut-1-yl)amino-2'-fluorodiphenylamine

1-(2-fluoro-phenyl)-1,4-dihydro-quinoxaline-2,3-dione

Refernces

• 1、 Liu, Ju,Yang, Di,Yang, Xiuxiu,Nie, Minhua,Wu, Guodong,Wang, Zhunchao,Li, Wei,Liu, Yajing,Gong, Ping. "Design, synthesis and biological evaluation of novel 4-phenoxyquinoline derivatives containing 3-oxo-3,4-dihydroquinoxaline moiety as c-Met kinase inhibitors". . p. 4475 - 4486. Retrieved 2017/07/22.
• 2、 Neudorfer, Catharina,Seddik, Amir,Shanab, Karem,Jurik, Andreas,Rami-Mark, Christina,Holzer, Wolfgang,Ecker, Gerhard,Mitterhauser, Markus,Wadsak, Wolfgang,Spreitzer, Helmut. "Synthesis and in silico evaluation of novel compounds for PET-based investigations of the norepinephrine transporter". . p. 1712 - 1730. Retrieved 2015/01/30.