N1-(2-Fluorophenyl)benzene-1,2-diamine

Base Information

• Chemical Name: N1-(2-Fluorophenyl)benzene-1,2-diamine
• CAS No.: 28898-03-5
• Molecular Formula: C12H11 F N2
• Molecular Weight: 202.231
• Hs Code.: 2921519090
• DSSTox Substance ID: DTXSID10597633
• Wikidata: Q72475794
• Mol file: 28898-03-5.mol

Synonyms:28898-03-5;N1-(2-Fluorophenyl)benzene-1,2-diamine;N-(2-Fluorophenyl)-1,2-diaminobenzene;2-Amino-2'-fluorodiphenylamine;2-N-(2-Fluorophenyl)benzene-1,2-diamine;1,2-Benzenediamine, N1-(2-fluorophenyl)-;N~1~-(2-Fluorophenyl)benzene-1,2-diamine;2-[(2-Fluorophenyl)amino]aniline;MFCD10567164;N-(2-fluorophenyl)-1,2-Benzenediamine;1,2-Benzenediamine,N1-(2-fluorophenyl)-;SCHEMBL3607119;DTXSID10597633;OYGRPIXAYJLZEN-UHFFFAOYSA-N;2-[(2-Fluorophenyl)amine]aniline;AKOS009281774;SB77808;N-(2-fluorophenyl)benzene-1,2-diamine;PS-10957;SY316907;N~1~-(2-fluorophenyl)-1,2-benzenediamine;CS-0060476;EN300-7415360;AS-813/43501974;Z367657596;N1-(2-Fluorophenyl)benzene-1,2-diamine, 2-Amino-2'-fluorodiphenylamine

Chemical Property of N1-(2-Fluorophenyl)benzene-1,2-diamine

Chemical Property:

• PSA: 38.05000
• LogP: 3.80570
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 202.09062652
• Heavy Atom Count: 15
• Complexity: 198

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-2''-fluorodiphenylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)N)NC2=CC=CC=C2F
• Uses: 2-Amino-2''-fluorodiphenylamine is a useful intermediate for the synthesis of fluorophenazines.

Technology Process of N1-(2-Fluorophenyl)benzene-1,2-diamine

There total 5 articles about N1-(2-Fluorophenyl)benzene-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(2-Fluorophenyl)-2-nitrobenzeneamine (28898-02-4) → N-(2-fluorophenyl)benzene-1,2-diamine (28898-03-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃; for 4h; under 760.051 Torr;

Reference yield:

2-Fluoroaniline (348-54-9) → N-(2-fluorophenyl)benzene-1,2-diamine (28898-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / KF / 20 h / 180 °C

2: 76 percent / K₂CO₃, Na₂S₂O₄ / ethanol; H₂O / 3 h / 23 °C

With potassium fluoride; sodium dithionite; potassium carbonate; In ethanol; water;

DOI:10.1002/ardp.19973301107

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → N-(2-fluorophenyl)benzene-1,2-diamine (28898-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / KF / 20 h / 180 °C

2: 76 percent / K₂CO₃, Na₂S₂O₄ / ethanol; H₂O / 3 h / 23 °C

With potassium fluoride; sodium dithionite; potassium carbonate; In ethanol; water;

DOI:10.1002/ardp.19973301107

upstream raw materials:

N-(2-Fluorophenyl)-2-nitrobenzeneamine

2-Fluoroaniline

ortho-nitrofluorobenzene

2-Chloronitrobenzene

Downstream raw materials:

2-fluoro-2'-(3-methylbut-1-yl)aminodiphenylamine

2-(3,3-dimethylbut-1-yl)amino-2'-fluorodiphenylamine

2-(2-cyclopentylethyl)amino-2'-fluorodiphenylamine

3-amino-2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine