28898-02-4

Basic information

• Product Name: 2-FLUORO-2'-NITRODIPHENYLAMINE
• Synonyms: 2-[(2-Fluorophenyl)amino]nitrobenzene;2-Fluoro-N-(2-nitrophenyl)aniline, 2-Fluoro-2'-nitrodiphenylamine;2-Fluoro-N-(2-nitrophenyl)aniline;2-FLUORO-2'-NITRODIPHENYLAMINE
• CAS NO: 28898-02-4
• Molecular Formula: C₁₂H₉FN₂O₂
• Molecular Weight: 232.2104632
• Product Categories: Fluorine series
• Mol File: 28898-02-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 326.4 °C at 760 mmHg
• Flash Point: 151.2 °C
• Appearance: /
• Density: 1.353 g/cm³
• Vapor Pressure: 0.000216mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: 2-FLUORO-2'-NITRODIPHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-2'-NITRODIPHENYLAMINE(28898-02-4)
• EPA Substance Registry System: 2-FLUORO-2'-NITRODIPHENYLAMINE(28898-02-4)

Safety Data

• Hazardous Substances Data: 28898-02-4(Hazardous Substances Data)

Usage

Description

2-FLUORO-2'-NITRODIPHENYLAMINE is a chemical compound characterized by the molecular formula C12H9FN2O2. It is a nitro diphenylamine derivative that features a fluorine atom attached to the second carbon in the phenyl ring. 2-FLUORO-2'-NITRODIPHENYLAMINE is recognized for its role as a building block in organic synthesis and pharmaceutical research, with applications extending to the manufacturing of agrochemicals and pharmaceuticals. It also serves as a reagent in chemical reactions and a precursor in the synthesis of various organic compounds. Due to its potential health and environmental hazards, it is crucial to handle and dispose of 2-FLUORO-2'-NITRODIPHENYLAMINE with care, adhering to established safety protocols.

Uses

Used in Organic Synthesis:
2-FLUORO-2'-NITRODIPHENYLAMINE is used as a building block for the synthesis of complex organic molecules, facilitating the creation of a wide range of chemical compounds with diverse applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-FLUORO-2'-NITRODIPHENYLAMINE is utilized as a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Manufacturing:
2-FLUORO-2'-NITRODIPHENYLAMINE is employed as a starting material in the production of agrochemicals, which are essential for crop protection and enhancement of agricultural yields.
Used in Chemical Reactions as a Reagent:
2-FLUORO-2'-NITRODIPHENYLAMINE is used as a reagent in various chemical reactions, aiding in the transformation of other substances and facilitating specific chemical processes.
Used as a Precursor in Synthesis:
2-FLUORO-2'-NITRODIPHENYLAMINE serves as a precursor in the synthesis of a variety of organic compounds, playing a crucial role in the formation of new chemical entities with potential applications in different industries.

InChI:InChI=1/C12H9FN2O2/c13-9-5-1-2-6-10(9)14-11-7-3-4-8-12(11)15(16)17/h1-8,14H

Upstream product

• 348-54-9 2-Fluoroaniline 
• 88-73-3 2-Chloronitrobenzene 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 88-74-4 2-nitro-aniline 
• 12775-96-1 copper 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 28898-03-5 N-(2-fluorophenyl)benzene-1,2-diamine 
• 1429049-13-7 N¹-(2-aminophenyl)-N¹-butyl-N²-(2-fluorophenyl)-N²-methylbenzene-1,2-diamine 
• 1429049-19-3 N-methyl-2-(10-methylphenazin-5(10H)-yl)aniline tosylate 
• 1429049-08-0 N¹-butyl-N²-(2-fluorophenyl)-N²-methyl-N¹-(2-nitrophenyl)benzene-1,2-diamine 
• 1429049-05-7 N¹-(2-fluorophenyl)-N¹,N²-dimethyl-N²-(2-nitrophenyl)benzene-1,2-diamine 
• 1429049-10-4 N¹-(2-aminophenyl)-N²-(2-fluorophenyl)-N¹,N²-dimethylbenzene-1,2-diamine 
• 1429049-03-5 N¹-(2-fluorophenyl)-N¹-methyl-N²-(2-nitrophenyl)benzene-1,2-diamine 
• 908242-59-1 N¹-(2-fluorophenyl)-N¹-methylbenzene-1,2-diamine 
• 1429049-16-0 N-butyl-2-(10-methylphenazin-5(10H)-yl)aniline 
• 1429049-15-9 N-methyl-2-(10-methylphenazin-5(10H)-yl)aniline 

Relevant articles and documents

Light-emitting copper compound based on benzimidazole diphosphine ligand and preparation method of light-emitting copper compound

The invention belongs to the technical field of organic complex synthesis, and relates to a light-emitting copper compound based on a benzimidazole diphosphine ligand and a preparation method of the light-emitting copper compound. The molecular formula of the light-emitting copper compound based on the benzimidazole diphosphine ligand is C43H32CuXN2P2, and the structural formula of the light-emitting copper compound based on the benzimidazole diphosphine ligand is shown as a formula I in the specification. The light-emitting copper compound has strong absorption (epsilon> 5 * 10 L.mol . cm ) near 230 nm, and medium-intensity absorption in a range of 280-300nm, the highest luminous quantum efficiency at 293K reaches 71.53% and the longest service life reaches 61.08 microseconds, so that the light-emitting copper compound is an efficient OLED photoluminescent material and can be applied to the field of preparation of OLED luminescent materials.

Synthesis and biological evaluation of novel pyrazole carboxamide with diarylamine-modi?ed scaffold as potent antifungal agents

Twenty-seven novel pyrazole carboxamides with diarylamine-modi?ed scaffold were designed, synthesized and characterized in detail via 1H NMR, 13C NMR, IR and ESI-HRMS. Preliminary bioassays showed that some of the target compounds exhibited good antifungal activity against Rhizoctonia solani, Rhizoctonia cerealis and Sclerotinia sclerotiorum. Among them, compound 9c-7 exhibited the highest antifungal activities against R. solani, R. cerealis and S. sclerotiorum in vitro with IC50 values of 0.013, 1.608 and 1.874?μg/mL, respectively. Notably, compound 9c-7 still presented the highest fungicidal activities against R. solani in vivo with an IC50 value of 22.21?μg/mL. Molecular docking simulation results reveal that compound 9c-7 binds well to the hydrophobic pockets of the receptor protein succinate dehydrogenase. This study suggests that compound 9c-7 could act as a potential fungicide to be used for further optimization.

Synthesis and in silico evaluation of novel compounds for PET-based investigations of the norepinephrine transporter

Since the norepinephrine transporter (NET) is involved in a variety of diseases, the investigation of underlying dysregulation-mechanisms of the norepinephrine (NE) system is of major interest. Based on the previously described highly potent and selective NET ligand 1-(3-(methylamino)-1-phenylpropyl)-3-phenyl-1,3-dihydro-2H-benzimidaz- ol-2-one (Me@APPI), this paper aims at the development of several fluorinated methylaminebased analogs of this compound. The newly synthesized compounds were computationally evaluated for their interactions with the monoamine transporters and represent reference compounds for PET-based investigation of the NET.