4-(2,4-Dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

Base Information

Chemical Name:4-(2,4-Dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid
CAS No.:1057292-60-0
Molecular Formula:C₂₂H₁₆Cl₂N₂O₄
Molecular Weight:443.286
Hs Code.:

Synonyms:4-(2,4-Dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

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Chemical Property of 4-(2,4-Dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

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Technology Process of 4-(2,4-Dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

There total 5 articles about 4-(2,4-Dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 915296-82-1
benzyl 4-(2,4-dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate

: 1057292-60-0
4-(2,4-Dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jm4008906

Reference yield:

: 915296-79-6
(Z)-ethyl 4-chloro-2-(2,4-dichlorobenzylidene)-3-oxobutanoate

: 1057292-60-0
4-(2,4-Dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: isopropyl alcohol / 18 h / 20 °C / Inert atmosphere

2: acetic acid; nitric acid / water / 18 h / 20 °C / Inert atmosphere

3: ethanol / 0.25 h / Microwave irradiation; Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; nitric acid; acetic acid; In ethanol; water; ethyl acetate; isopropyl alcohol;
DOI:10.1021/jm4008906

Reference yield:

: 915296-80-9
3-benzyl 5-ethyl 6-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate

: 1057292-60-0
4-(2,4-Dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; nitric acid / water / 18 h / 20 °C / Inert atmosphere

2: ethanol / 0.25 h / Microwave irradiation; Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; nitric acid; acetic acid; In ethanol; water; ethyl acetate;
DOI:10.1021/jm4008906