tert-butyl (S)-1-(cyclohexylcarbamoyl)-2-hydroxyethylcarbamate

Base Information

• Chemical Name: tert-butyl (S)-1-(cyclohexylcarbamoyl)-2-hydroxyethylcarbamate
• CAS No.: 130776-37-3
• Molecular Formula: C₁₄H₂₆N₂O₄
• Molecular Weight: 286.371
• Mol file: 130776-37-3.mol

Synonyms:tert-butyl (S)-1-(cyclohexylcarbamoyl)-2-hydroxyethylcarbamate

Chemical Property of tert-butyl (S)-1-(cyclohexylcarbamoyl)-2-hydroxyethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of tert-butyl (S)-1-(cyclohexylcarbamoyl)-2-hydroxyethylcarbamate

There total 1 articles about tert-butyl (S)-1-(cyclohexylcarbamoyl)-2-hydroxyethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-(tert-butoxycarbonyl)serine (3262-72-4) + cyclohexylamine (108-91-8,157973-60-9) → tert-butyl (S)-1-(cyclohexylcarbamoyl)-2-hydroxyethylcarbamate (130776-37-3)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1) CH₂Cl₂, -15 deg C, 10 min, 2) 1 h, rt;

DOI:10.1016/S0040-4039(00)92178-6

Reference yield: 99.0%

tert-butyl (S)-1-(cyclohexylcarbamoyl)-2-hydroxyethylcarbamate (130776-37-3) → (S)-2-amino-N-cyclohexyl-3-hydroxypropanamide (70118-39-7)

Guidance literature:

With water; at 100 ℃; for 4h;

DOI:10.1039/b910239f

Reference yield: 80.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + tert-butyl (S)-1-(cyclohexylcarbamoyl)-2-hydroxyethylcarbamate (130776-37-3) → Boc-SerNHcHex (137320-53-7)

Guidance literature:

With 1H-tetrazole; In dichloromethane;

DOI:10.1016/S0040-4039(00)92178-6

upstream raw materials:

(S)-N-(tert-butoxycarbonyl)serine

cyclohexylamine

Downstream raw materials:

Boc-SerNHcHex

(S)-2-amino-N-cyclohexyl-3-hydroxypropanamide