E₂₅₀₈ Tosylate

Base Information

Chemical Name:E₂₅₀₈ Tosylate
CAS No.:685886-34-4
Molecular Formula:C₇H₈O₃S*C₂₉H₃₉N₃O₄
Molecular Weight:665.851
Hs Code.:

Synonyms:E₂₅₀₈ Tosylate

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Chemical Property of E₂₅₀₈ Tosylate

Chemical Property:

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Technology Process of E₂₅₀₈ Tosylate

There total 9 articles about E₂₅₀₈ Tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 685885-75-0
N-(cyclopropylmethyl)-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]pyrazolo[1,5-a]pyridin-3-amine

: 104-15-4
toluene-4-sulfonic acid

: 685886-34-4
E₂₅₀₈ Tosylate

Guidance literature:: In ethyl acetate; at 20 ℃;
DOI:10.1021/jm300259r

Reference yield:

: 109-04-6
2-bromo-pyridine

: 685886-34-4
E₂₅₀₈ Tosylate

Guidance literature:: Multi-step reaction with 12 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / diethylamine / 10 h / 20 °C

2.1: dichloromethane / 1 h / 0 °C / Cooling with ice

3.1: sodium methylate / methanol / 0.5 h / 0 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

4.2: 0.17 h / -78 °C / Inert atmosphere

5.1: nitronium tetrafluoborate / acetonitrile / 0.17 h / 0 °C / Cooling with ice

6.1: acetic acid; zinc / ethanol; water / 0.33 h / 20 - 60 °C

7.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Cooling with ice

8.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

8.2: 1 h / 20 - 40 °C

9.1: hydrogenchloride / ethyl acetate / 0.5 h / 20 - 40 °C

10.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 0.5 h / 20 °C

11.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

12.1: ethyl acetate / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; nitronium tetrafluoborate; barium hydroxide octahydrate; sodium methylate; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; triethylamine; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; ethyl acetate; diethylamine; N,N-dimethyl-formamide; acetonitrile; 11.1: Suzuki coupling;
DOI:10.1021/jm300259r

Reference yield:

: 685886-45-7
7-bromo-2-ethylpyrazolo[1,5-a]pyridine-3-amine

: 685886-34-4
E₂₅₀₈ Tosylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 - 40 °C

3.1: hydrogenchloride / ethyl acetate / 0.5 h / 20 - 40 °C

4.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 0.5 h / 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

6.1: ethyl acetate / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate; sodium tris(acetoxy)borohydride; sodium hydride; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 5.1: Suzuki coupling;
DOI:10.1021/jm300259r