2-(4-Amino-phenyl)-7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

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Chemical Name:2-(4-Amino-phenyl)-7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one
CAS No.:1313365-34-2
Molecular Formula:C₂₆H₂₇ClN₂O₃
Molecular Weight:450.965
Hs Code.:

Synonyms:2-(4-Amino-phenyl)-7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

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Chemical Property of 2-(4-Amino-phenyl)-7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

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Technology Process of 2-(4-Amino-phenyl)-7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

There total 8 articles about 2-(4-Amino-phenyl)-7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1313365-33-1
7-((R)-sec-Butoxy)-1-(4-chloro-phenyl)-6-methoxy-2-(4-nitro-phenyl)-1,4-dihydro-2H-isoquinolin-3-one

: 1313365-34-2
2-(4-Amino-phenyl)-7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: With iron; acetic acid; In water; ethyl acetate; at 80 ℃; for 1h;
DOI:10.1016/j.bmcl.2015.06.058

Reference yield:

: C₁₄H₂₀O₄

: 1313365-34-2
2-(4-Amino-phenyl)-7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide; water / ethanol / 2 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3.1: dichloromethane / 1 h / 20 °C

3.2: 0.25 h / 0 °C

4.1: iron; acetic acid / ethyl acetate; water / 1 h / 80 °C

With oxalyl dichloride; water; iron; acetic acid; N,N-dimethyl-formamide; lithium hydroxide; In ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.bmcl.2015.06.058

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1313365-34-2
2-(4-Amino-phenyl)-7-((R)-sec-butoxy)-1-(4-chloro-phenyl)-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: neat (no solvent) / 72 h / 20 °C

2.1: dichloromethane / 1 h / 20 °C

2.2: 0.25 h / 0 °C

3.1: iron; acetic acid / ethyl acetate; water / 1 h / 80 °C

With iron; acetic acid; In dichloromethane; water; ethyl acetate;
DOI:10.1016/j.bmcl.2015.06.058