methyl 1-(4-methoxyphenyl)-6,7-[oxybis(dimethylsilanediyl)]-3a,4,9,9a-tetrahydro-4,9-epoxy-1H-benzo[f]indazole-3-carboxylate

Base Information

• Chemical Name: methyl 1-(4-methoxyphenyl)-6,7-[oxybis(dimethylsilanediyl)]-3a,4,9,9a-tetrahydro-4,9-epoxy-1H-benzo[f]indazole-3-carboxylate
• CAS No.: 1391763-07-7
• Molecular Formula: C₂₄H₂₈N₂O₅Si₂
• Molecular Weight: 480.668
• Mol file: 1391763-07-7.mol

Synonyms:methyl 1-(4-methoxyphenyl)-6,7-[oxybis(dimethylsilanediyl)]-3a,4,9,9a-tetrahydro-4,9-epoxy-1H-benzo[f]indazole-3-carboxylate

Chemical Property of methyl 1-(4-methoxyphenyl)-6,7-[oxybis(dimethylsilanediyl)]-3a,4,9,9a-tetrahydro-4,9-epoxy-1H-benzo[f]indazole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-(4-methoxyphenyl)-6,7-[oxybis(dimethylsilanediyl)]-3a,4,9,9a-tetrahydro-4,9-epoxy-1H-benzo[f]indazole-3-carboxylate

There total 3 articles about methyl 1-(4-methoxyphenyl)-6,7-[oxybis(dimethylsilanediyl)]-3a,4,9,9a-tetrahydro-4,9-epoxy-1H-benzo[f]indazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C14H18O2Si2 (442912-17-6) + C9H8N2O2ClCH3O (70736-27-5) → methyl 1-(4-methoxyphenyl)-6,7-[oxybis(dimethylsilanediyl)]-3a,4,9,9a-tetrahydro-4,9-epoxy-1H-benzo[f]indazole-3-carboxylate (1391763-07-7)

Guidance literature:

With triethylamine; In chloroform; at 50 ℃; for 6h; Inert atmosphere;

DOI:10.1002/ejoc.201300110

Reference yield:

C19H26F3IO5SSi3 → methyl 1-(4-methoxyphenyl)-6,7-[oxybis(dimethylsilanediyl)]-3a,4,9,9a-tetrahydro-4,9-epoxy-1H-benzo[f]indazole-3-carboxylate (1391763-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride; diisopropylamine / tetrahydrofuran / 20 °C

2: triethylamine / chloroform / 6 h / 50 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; triethylamine; diisopropylamine; In tetrahydrofuran; chloroform;

DOI:10.1002/ejoc.201300110

Reference yield:

1,3,5,7-tetrahydro-1,1,3,3,5,5,7,7-octamethylbenzo[1,2-c:4,5-c']bis[1,2,5]oxadisilole (51118-21-9) → methyl 1-(4-methoxyphenyl)-6,7-[oxybis(dimethylsilanediyl)]-3a,4,9,9a-tetrahydro-4,9-epoxy-1H-benzo[f]indazole-3-carboxylate (1391763-07-7)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluorormethanesulfonic acid / dichloromethane / 0 - 20 °C

2: tetrabutyl ammonium fluoride; diisopropylamine / tetrahydrofuran / 20 °C

3: triethylamine / chloroform / 6 h / 50 °C / Inert atmosphere

With trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; triethylamine; diisopropylamine; In tetrahydrofuran; dichloromethane; chloroform;

DOI:10.1002/ejoc.201300110

upstream raw materials:

1,3,5,7-tetrahydro-1,1,3,3,5,5,7,7-octamethylbenzo[1,2-c:4,5-c']bis[1,2,5]oxadisilole

C₁₄H₁₈O₂Si₂

C₉H₈N₂O₂ClCH₃O

Downstream raw materials:

methyl 1-(4-methoxyphenyl)-6,7-[oxybis(dimethylsilanediyl)]-1H-benzo[f]indazole-3-carboxylate