4-[8-(3-bromo-4-chlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoic acid formate

Base Information

Chemical Name:4-[8-(3-bromo-4-chlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoic acid formate
CAS No.:1360917-76-5
Molecular Formula:CH₂O₂*C₂₁H₂₀BrClN₂O₄
Molecular Weight:525.783
Hs Code.:

Synonyms:4-[8-(3-bromo-4-chlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoic acid formate

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Chemical Property of 4-[8-(3-bromo-4-chlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoic acid formate

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Technology Process of 4-[8-(3-bromo-4-chlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoic acid formate

There total 4 articles about 4-[8-(3-bromo-4-chlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoic acid formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-18-6
formic acid

: 1360914-54-0
4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoic acid hydrochloride

: 86265-88-5
3-bromo-4-chloro-benzaldehyde

: 1360917-76-5
4-[8-(3-bromo-4-chlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoic acid formate

Guidance literature:: 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoic acid hydrochloride; 3-bromo-4-chloro-benzaldehyde; With acetic acid; In N,N-dimethyl-formamide; at 20 ℃;

formic acid; In water; acetonitrile;

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 1360917-76-5
4-[8-(3-bromo-4-chlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoic acid formate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / 18 h / Inert atmosphere; Heating

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: water; lithium hydroxide monohydrate / methanol / 4 h / 55 °C

3.2: 20 °C / pH ~ 5

4.1: acetic acid / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; caesium carbonate; acetic acid; copper(l) iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 169206-55-7
2-oxo-1-oxa-3,8-diazaspiro<4.5>decane-8-carboxylic acid tert-butyl ester

: 1360917-76-5
4-[8-(3-bromo-4-chlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoic acid formate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / 18 h / Inert atmosphere; Heating

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: water; lithium hydroxide monohydrate / methanol / 4 h / 55 °C

3.2: 20 °C / pH ~ 5

4.1: acetic acid / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; caesium carbonate; acetic acid; copper(l) iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;