Phosphoric acid (2R,3S,5S)-2,5-bis-(4,5-dimethoxy-2-nitro-benzyloxy)-2-(dimethoxy-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester dimethyl ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5S)-2,5-bis-(4,5-dimethoxy-2-nitro-benzyloxy)-2-(dimethoxy-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester dimethyl ester
• CAS No.: 868367-88-8
• Molecular Formula: C₂₇H₃₈N₂O₁₉P₂
• Molecular Weight: 756.548
• Mol file: 868367-88-8.mol

Synonyms:Phosphoric acid (2R,3S,5S)-2,5-bis-(4,5-dimethoxy-2-nitro-benzyloxy)-2-(dimethoxy-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester dimethyl ester

Chemical Property of Phosphoric acid (2R,3S,5S)-2,5-bis-(4,5-dimethoxy-2-nitro-benzyloxy)-2-(dimethoxy-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3S,5S)-2,5-bis-(4,5-dimethoxy-2-nitro-benzyloxy)-2-(dimethoxy-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester dimethyl ester

There total 1 articles about Phosphoric acid (2R,3S,5S)-2,5-bis-(4,5-dimethoxy-2-nitro-benzyloxy)-2-(dimethoxy-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

dimethyl N,N-diisopropylphosphoramidite (122194-07-4) + (2R,3S,5S)-2,5-Bis-(4,5-dimethoxy-2-nitro-benzyloxy)-2-hydroxymethyl-tetrahydro-furan-3-ol (657357-51-2) → Phosphoric acid (2R,3S,5S)-2,5-bis-(4,5-dimethoxy-2-nitro-benzyloxy)-2-(dimethoxy-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester dimethyl ester (868367-88-8)

Guidance literature:

dimethyl N,N-diisopropylphosphoramidite; (2R,3S,5S)-2,5-Bis-(4,5-dimethoxy-2-nitro-benzyloxy)-2-hydroxymethyl-tetrahydro-furan-3-ol; With terazole; In acetonitrile; for 0.5h;

With tert.-butylhydroperoxide; In decane; acetonitrile; for 2h;

DOI:10.1021/jo0512249

Reference yield:

Phosphoric acid (2R,3S,5S)-2,5-bis-(4,5-dimethoxy-2-nitro-benzyloxy)-2-(dimethoxy-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester dimethyl ester (868367-88-8) → C25H32N2O19P2(2-)*2Na(1+)

Guidance literature:

With sodium iodide; In acetone; for 6h; Heating;

DOI:10.1021/jo0512249

upstream raw materials:

dimethyl N,N-diisopropylphosphoramidite

(2R,3S,5S)-2,5-Bis-(4,5-dimethoxy-2-nitro-benzyloxy)-2-hydroxymethyl-tetrahydro-furan-3-ol