122194-07-4

Usage

Uses

A useful reagent for the efficient phosphorylation of alcohols.

Upstream product

• 124-41-4 sodium methylate 
• 86030-43-5 N,N-diisopropylmethylphosphonamidic chloride 
• 67-56-1 methanol 
• 921-26-6 N,N-diisopropylphosphoramide dichloride 
• 108-18-9 diisopropylamine 
• 56183-63-2 bis(diisopropylamino)chlorophosphine 
• 92611-10-4 bis(N,N-diisopropylamino)methoxyphosphine 
• 96163-52-9 methyl N,N-diisopropylphosphonamidate 

Downstream Products

• 146578-13-4 Phosphorous acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylmethyl ester dimethyl ester 
• 122194-08-5 4-Nitro-benzoic acid (2R,3S,5R)-3-(dimethoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 302808-96-4 dimethyl 2-(4-methoxyphenyl)-2-propen-1-yl phosphite 
• 868367-88-8 Phosphoric acid (2R,3S,5S)-2,5-bis-(4,5-dimethoxy-2-nitro-benzyloxy)-2-(dimethoxy-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester dimethyl ester 
• 868367-89-9 Phosphoric acid (2S,3S,5R)-2,5-bis-(4,5-dimethoxy-2-nitro-benzyloxy)-2-(dimethoxy-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester dimethyl ester 
• 922712-30-9 1D-1-O-(tert-butyldiphenylsilyl)-3-O-benzoyl-2,6-O-bis(methoxymethylene)-4,5-bis(dimethylphosphate)-myo-inositol 
• 922712-36-5 1D-1-O-(tert-butyldiphenylsilyl)-3-(dimethylmethylenephosphonate)-2,6-O-bis(methoxymethylene)-4,5-bis(dimethylphosphate)-myo-inositol 
• 208466-14-2 Phosphorous acid dimethyl ester (3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl ester 
• 1374660-13-5 meso-4,6-Di-O-benzyl-D-myo-inositol-1,3,5-tri(dimethyl phosphate)-2-(didecyl phosphate) 
• 868-85-9 Dimethyl phosphite 
• 27356-57-6 dimethyl (2-phenylaziridin-1-yl) phosphate 

Relevant academic research and scientific papers

Phosphoric acid phaseomannite class compound and its preparation method and application (by machine translation)

The invention discloses a phaseomannite class phosphate compound, phosphoric acid phaseomannite class compound preparation method, and these phosphoric acid phaseomannite class compounds in the preparation of an anti-tumor drug. The use of non-small cell lung cancer cells to the compounds of this invention to inhibit the growth of tumor cells in active testing, that the compounds of this invention have high inhibition of tumor cell growth activity, some of the compound inhibiting activity even with cisplatin active quite, which indicates that the compounds of this invention have good cell penetrability and phosphorus esterase stability, can be used for the development of anti-tumor medicament. (by machine translation)

Laser flash photolysis evidence for styryl radical cation cyclization in the SET-induced photorearrangement of a p-methoxy-substituted 2-phenylallyl phosphite

The SET-induced photorearrangement of dimethyl 2-(4-methoxyphenyl)allyl phosphite, 9 (UV light, uranium glass filter, 9,10-dicyanoanthracene (DCA), biphenyl), gives phosphonate 12 in 83% isolated yield. Laser flash irradiation at 355 nm of oxygen saturate

Kinetics and mechanism of tetrazole-catalyzed phosphoramidite alcoholysis

Kinetics of the tetrazole-catalyzed reaction of diisopropyl N,N-diisopropylphosphoramidite (1b) with tert-butyl alcohol has been studied by 31P NMR spectroscopy in THF, and the results obtained have been compared to those observed for the possible partial reactions involved, viz. the formation of diisopropyl tetrazolylphosphite (2b) and its subsequent alcoholysis. The stoichiometry of the processes was first examined with dimethyl N,N-diisopropylphosphoramidite (1a) in MeCN. The tetrazole-promoted disappearance of 1b is as fast in the absence and in the presence of the alcohol: the alcoholysis of 1b is zero-order in the concentration of alcohol and second-order in the concentration of tetrazole. The reaction of 1b with tetrazole is independent of the concentration of the tetrazolide anion and second-order in that of tetrazole, while the reverse reaction, aminolysis of 2b is first-order in the concentration of the amine The alcoholysis of 2b is, in turn, first-order in the concentration of alcohol and second-order in that of tetrazole, but it also proceeds, although slowly, in the absence of tetrazole. The time-dependent product distribution of the alcoholysis of 1b shows intermediary accumulation of 2b, but at a lower level than could be predicted by applying the rate constants determined independently for the assumed partial reactions. Accordingly, tetrazole-catalyzed alcoholysis of 1b is shown to proceed at least mainly via 2b, but an additional pathway not involving 2b as an intermediate is proposed. Mechanisms of the partial reactions are discussed on the basis of the formal kinetics observed.

Synthesis of [35S]phosphorothionate insecticides: The example of [35S]fenthion

A general method for the synthesis of [35S]phosphorothionates is proposed, based on the example of [35S]fenthion. This consists of reacting molecular 35S with the corresponding phosphites which are easily prepared from commercial precursors.

Nucleoside 3'-N,N-dialkylphosphonamidates: Novel building blocks for oligonucleotide synthesis

Nucleoside 3'-N,N-diisopropylphosphonamidates reacted with tris(2,4,6-tribromophenoxy)dichlorophosphorane (BDCP) to generate the corresponding aminophosphorochloridites without cleavage of the P-N bond. The reaction was applied to internucleotidic bond formation.

Amidine Protecting Groups for Oligonucleotide Synthesis

Amidines have been investigated for protection of deoxyadenosine, deoxycytidine, 5-methyldeoxycytidine, cytidine, and deoxyguanosine.These amidine-protected nucleosides and their 5'-bis(p-anisylphenyl)methyl derivatives were prepared in high yield (79-100