Dimethyl N,N-diisopropylphosphoramidite

Base Information

• Chemical Name: Dimethyl N,N-diisopropylphosphoramidite
• CAS No.: 122194-07-4
• Molecular Formula: C8H20 N O2 P
• Molecular Weight: 193.226
• Hs Code.: 2929 90 00
• European Community (EC) Number: 635-017-8
• Nikkaji Number: J986.174B
• Mol file: 122194-07-4.mol

Synonyms:Dimethyl N,N-diisopropylphosphoramidite;122194-07-4;29952-64-5;N-dimethoxyphosphanyl-N-propan-2-ylpropan-2-amine;dimethyl-n,n-diisopropylphosphoramidite;Phosphoramidous acid, N,N-bis(1-methylethyl)-, dimethyl ester;C8H20NO2P;(dimethoxyphosphanyl)bis(propan-2-yl)amine;DIMETHYLN,N-DIISOPROPYLPHOSPHORAMIDITE;SCHEMBL385951;MFCD00153505;AKOS006346191;AS-71128;FT-0625089;C71838;J-004771;Dimethyl N,N-diisopropylphosphoramidite, >=95.0% (GC)

Chemical Property of Dimethyl N,N-diisopropylphosphoramidite

Chemical Property:

• Refractive Index: n20/D 1.420(lit.)
• Boiling Point: 54 °C10 mm Hg(lit.)
• Flash Point: 100 °C
• PSA: 35.29000
• Density: 0.840 g/mL at 20 °C(lit.)
• LogP: 2.62490
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Sparingly), Ethyl Acetate (Sparingly)
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 193.12316588
• Heavy Atom Count: 12
• Complexity: 108

Purity/Quality:

98%,99%, ^*data from raw suppliers

Dimethyl N,N-diisopropylphosphoramidite ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)N(C(C)C)P(OC)OC
• Uses: A useful reagent for the efficient phosphorylation of alcohols.

Technology Process of Dimethyl N,N-diisopropylphosphoramidite

There total 7 articles about Dimethyl N,N-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

sodium methylate (124-41-4) + N,N-diisopropylmethylphosphonamidic chloride (86030-43-5) → dimethyl N,N-diisopropylphosphoramidite (122194-07-4)

Guidance literature:

In tetrahydrofuran; at -35 - 20 ℃;

DOI:10.1002/jlcr.2580340110

Reference yield: 49.0%

methanol (67-56-1) + N,N-diisopropylphosphoramide dichloride (921-26-6) → dimethyl N,N-diisopropylphosphoramidite (122194-07-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In hexane; for 2h; Ambient temperature;

DOI:10.1039/a801250d

Reference yield:

methanol (67-56-1) + bis(diisopropylamino)chlorophosphine (56183-63-2) → dimethyl N,N-diisopropylphosphoramidite (122194-07-4)

Guidance literature:

With triethylamine; In diethyl ether; at 20 ℃;

DOI:10.1021/jo0006775

upstream raw materials:

methanol

methyl N,N-diisopropylphosphonamidate

bis(N,N-diisopropylamino)methoxyphosphine

sodium methylate

Downstream raw materials:

diisopropylamine

dimethyl 2-(4-methoxyphenyl)-2-propen-1-yl phosphite

1D-1-O-(tert-butyldiphenylsilyl)-3-O-benzoyl-2,6-O-bis(methoxymethylene)-4,5-bis(dimethylphosphate)-myo-inositol

1D-1-O-(tert-butyldiphenylsilyl)-3-(dimethylmethylenephosphonate)-2,6-O-bis(methoxymethylene)-4,5-bis(dimethylphosphate)-myo-inositol

Refernces

• 1、 Shukla, Deepak,Lu, Cuong,Schepp, Norman P.,Bentrude, Wesley G.,Johnston, Linda J.. "Laser flash photolysis evidence for styryl radical cation cyclization in the SET-induced photorearrangement of a p-methoxy-substituted 2-phenylallyl phosphite". . p. 6167 - 6172. Retrieved 2007/10/03.
• 2、 Dias,Mornet,Kotoujansky. "Synthesis of [35S]phosphorothionate insecticides: The example of [35S]fenthion". . p. 73 - 78. Retrieved 2007/10/02.