(E)-4-Methyl-6-[7-methyl-3-oxo-6-phenyl-4-(toluene-4-sulfonyloxy)-1,3-dihydro-isobenzofuran-5-yl]-hex-4-enoic acid methyl ester

Base Information

Chemical Name:(E)-4-Methyl-6-[7-methyl-3-oxo-6-phenyl-4-(toluene-4-sulfonyloxy)-1,3-dihydro-isobenzofuran-5-yl]-hex-4-enoic acid methyl ester
CAS No.:182010-05-5
Molecular Formula:C₃₀H₃₀O₇S
Molecular Weight:534.63
Hs Code.:

Synonyms:(E)-4-Methyl-6-[7-methyl-3-oxo-6-phenyl-4-(toluene-4-sulfonyloxy)-1,3-dihydro-isobenzofuran-5-yl]-hex-4-enoic acid methyl ester

Suppliers and Price of (E)-4-Methyl-6-[7-methyl-3-oxo-6-phenyl-4-(toluene-4-sulfonyloxy)-1,3-dihydro-isobenzofuran-5-yl]-hex-4-enoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-4-Methyl-6-[7-methyl-3-oxo-6-phenyl-4-(toluene-4-sulfonyloxy)-1,3-dihydro-isobenzofuran-5-yl]-hex-4-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-4-Methyl-6-[7-methyl-3-oxo-6-phenyl-4-(toluene-4-sulfonyloxy)-1,3-dihydro-isobenzofuran-5-yl]-hex-4-enoic acid methyl ester

There total 6 articles about (E)-4-Methyl-6-[7-methyl-3-oxo-6-phenyl-4-(toluene-4-sulfonyloxy)-1,3-dihydro-isobenzofuran-5-yl]-hex-4-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 960-16-7
tributylphenylstannane

: 171808-05-2
methyl (E) 6-(1,3-dihydro-7-methyl-3-oxo-4-p-toluenesulfonyloxy-6-trifluoromethanesulfonyloxy-isobenzofuran-5-yl)-4-methyl-4-hexenoate

: 182010-05-5
(E)-4-Methyl-6-[7-methyl-3-oxo-6-phenyl-4-(toluene-4-sulfonyloxy)-1,3-dihydro-isobenzofuran-5-yl]-hex-4-enoic acid methyl ester

Guidance literature:: With 1-methyl-pyrrolidin-2-one; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenyl-arsane; lithium chloride; at 95 ℃; for 3h;
DOI:10.1021/jm9603633

Reference yield:

: 31858-66-9
methyl mycophenolate

: 182010-05-5
(E)-4-Methyl-6-[7-methyl-3-oxo-6-phenyl-4-(toluene-4-sulfonyloxy)-1,3-dihydro-isobenzofuran-5-yl]-hex-4-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N, DMAP / CH₂Cl₂ / 1.5 h / 0 °C

2: collidine, LiI / 17 h / 70 °C

3: TsOH / 18 h / 25 °C

4: 92 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

5: 18 percent / LiCl, Ph₃As, tris(dibenzylideneacetone)dipalladium⁽⁰⁾*chloroform adduct, N-methylpyrrolidinone / 3 h / 95 °C

With pyridine; 1-methyl-pyrrolidin-2-one; 2,3,5-trimethyl-pyridine; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenyl-arsane; toluene-4-sulfonic acid; triethylamine; lithium chloride; lithium iodide; In dichloromethane;
DOI:10.1021/jm9603633

Reference yield:

: 24280-93-1
mycophenolic acid

: 182010-05-5
(E)-4-Methyl-6-[7-methyl-3-oxo-6-phenyl-4-(toluene-4-sulfonyloxy)-1,3-dihydro-isobenzofuran-5-yl]-hex-4-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / TsOH / 18 h / 25 °C

2: Et₃N, DMAP / CH₂Cl₂ / 1.5 h / 0 °C

3: collidine, LiI / 17 h / 70 °C

4: TsOH / 18 h / 25 °C

5: 92 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

6: 18 percent / LiCl, Ph₃As, tris(dibenzylideneacetone)dipalladium⁽⁰⁾*chloroform adduct, N-methylpyrrolidinone / 3 h / 95 °C

With pyridine; 1-methyl-pyrrolidin-2-one; 2,3,5-trimethyl-pyridine; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenyl-arsane; toluene-4-sulfonic acid; triethylamine; lithium chloride; lithium iodide; In dichloromethane;
DOI:10.1021/jm9603633