Technology Process of ((E)-(2S,3S,4S,5S)-3,5-dimethoxy-2,4-dimethyloct-6-enyloxymethyl)benzene
There total 1 articles about ((E)-(2S,3S,4S,5S)-3,5-dimethoxy-2,4-dimethyloct-6-enyloxymethyl)benzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
18-crown-6 ether; potassium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
Inert atmosphere;
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![(13E,15E)-(3S,6S,9R,10R,11S,12S,18R,21S)-3-(3-hydroxy-benzyl)-6-isopropyl-10,12-dimethoxy-9,11,18-trimethyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone](/Databaselist/images/loading.webp)
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1381808-97-4
(13E,15E)-(3S,6S,9R,10R,11S,12S,18R,21S)-3-(3-hydroxy-benzyl)-6-isopropyl-10,12-dimethoxy-9,11,18-trimethyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone
- Guidance literature:
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Multi-step reaction with 10 steps
1.1: lithium 4,4′-di-tert-butylbiphenylide / tetrahydrofuran / -78 - -70 °C / Inert atmosphere
1.2: -70 °C
2.1: pyridine / 2 h / 0 - 20 °C / Inert atmosphere
3.1: ozone / dichloromethane / -78 °C
3.2: -78 - 20 °C / Inert atmosphere
4.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
4.2: -78 - 20 °C / Inert atmosphere
5.1: sodium methylate; methanol / 20 °C / Inert atmosphere
6.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 3 h / 20 °C / Inert atmosphere; Molecular sieve
7.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 1.5 h / 20 °C
8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 18 h / 20 °C
9.1: Grubbs catalyst first generation / dichloromethane / 42 h / Reflux; Inert atmosphere
10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
With
pyridine; methanol; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; sodium methylate; lithium 4,4′-di-tert-butylbiphenylide; benzotriazol-1-ol; ozone; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
Grubbs catalyst first generation;
In
tetrahydrofuran; hexane; dichloromethane; water; acetonitrile; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: lithium 4,4′-di-tert-butylbiphenylide / tetrahydrofuran / -78 - -70 °C / Inert atmosphere
1.2: -70 °C
2.1: pyridine / 2 h / 0 - 20 °C / Inert atmosphere
3.1: ozone / dichloromethane / -78 °C
3.2: -78 - 20 °C / Inert atmosphere
4.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
4.2: -78 - 20 °C / Inert atmosphere
5.1: sodium methylate; methanol / 20 °C / Inert atmosphere
6.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 3 h / 20 °C / Inert atmosphere; Molecular sieve
7.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 1.5 h / 20 °C
8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 18 h / 20 °C
9.1: Grubbs catalyst first generation / dichloromethane / 42 h / Reflux; Inert atmosphere
With
pyridine; methanol; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; sodium methylate; lithium 4,4′-di-tert-butylbiphenylide; benzotriazol-1-ol; ozone; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
Grubbs catalyst first generation;
In
tetrahydrofuran; hexane; dichloromethane; water; acetonitrile; tert-butyl alcohol;
