4-{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-5-yloxy}-butyric acid ethyl ester

Base Information

Chemical Name:4-{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-5-yloxy}-butyric acid ethyl ester
CAS No.:182116-61-6
Molecular Formula:C₂₅H₂₇NO₄
Molecular Weight:405.494
Hs Code.:

Synonyms:4-{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-5-yloxy}-butyric acid ethyl ester

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Chemical Property of 4-{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-5-yloxy}-butyric acid ethyl ester

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Technology Process of 4-{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-5-yloxy}-butyric acid ethyl ester

There total 7 articles about 4-{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-5-yloxy}-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13048-81-2,40527-52-4,13048-80-1
(E)-3-(4-methoxyphenyl)-2-methylacrylic acid

: 182116-61-6
4-{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-5-yloxy}-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / H₂ / 10percent Pd/C / methanol / 2280 Torr

2: 39 percent / polyphosphoric acid / 2 h / 90 °C

3: 1.) NaH, 3.) NaOMe

4: 1.) Et₃N, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 2.) aq. NH₄OH / 1.) CH₃CN, RT, 45 min, 2.) CH₃CN, RT, 30 min

5: 49 percent / BBr₃ / CH₂Cl₂

6: 1.) NaH / 1.) DMF, RT, 60 min, 2.) DMF, a) 0 deg C, 45 min, b) RT, 75 min

With ammonium hydroxide; PPA; hydrogen; sodium methylate; boron tribromide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm960395q

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 182116-61-6
4-{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-5-yloxy}-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 76 percent / sodium propionate / 150 °C

2: 74 percent / H₂ / 10percent Pd/C / methanol / 2280 Torr

3: 39 percent / polyphosphoric acid / 2 h / 90 °C

4: 1.) NaH, 3.) NaOMe

5: 1.) Et₃N, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 2.) aq. NH₄OH / 1.) CH₃CN, RT, 45 min, 2.) CH₃CN, RT, 30 min

6: 49 percent / BBr₃ / CH₂Cl₂

7: 1.) NaH / 1.) DMF, RT, 60 min, 2.) DMF, a) 0 deg C, 45 min, b) RT, 75 min

With ammonium hydroxide; PPA; sodium proprionate; hydrogen; sodium methylate; boron tribromide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm960395q

Reference yield:

: 52427-11-9
3-(4-methoxyphenyl)-2-methylpropionic acid

: 182116-61-6
4-{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-5-yloxy}-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 39 percent / polyphosphoric acid / 2 h / 90 °C

2: 1.) NaH, 3.) NaOMe

3: 1.) Et₃N, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 2.) aq. NH₄OH / 1.) CH₃CN, RT, 45 min, 2.) CH₃CN, RT, 30 min

4: 49 percent / BBr₃ / CH₂Cl₂

5: 1.) NaH / 1.) DMF, RT, 60 min, 2.) DMF, a) 0 deg C, 45 min, b) RT, 75 min

With ammonium hydroxide; PPA; sodium methylate; boron tribromide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane;
DOI:10.1021/jm960395q