(R)-ethyl 3-((S)-1,1-dimethylethylsulfinylamino)-4,4-difluoro-3-(2-fluorophenyl)butanoate

Base Information

Chemical Name:(R)-ethyl 3-((S)-1,1-dimethylethylsulfinylamino)-4,4-difluoro-3-(2-fluorophenyl)butanoate
CAS No.:1448793-52-9
Molecular Formula:C₁₆H₂₂F₃NO₃S
Molecular Weight:365.417
Hs Code.:

Synonyms:(R)-ethyl 3-((S)-1,1-dimethylethylsulfinylamino)-4,4-difluoro-3-(2-fluorophenyl)butanoate

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Chemical Property of (R)-ethyl 3-((S)-1,1-dimethylethylsulfinylamino)-4,4-difluoro-3-(2-fluorophenyl)butanoate

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Technology Process of (R)-ethyl 3-((S)-1,1-dimethylethylsulfinylamino)-4,4-difluoro-3-(2-fluorophenyl)butanoate

There total 1 articles about (R)-ethyl 3-((S)-1,1-dimethylethylsulfinylamino)-4,4-difluoro-3-(2-fluorophenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.2%

: 1448793-50-7
(S,Z)-N-(2,2-difluoro-1-(2-fluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 105-36-2
ethyl bromoacetate

: 1448793-51-8
(R)-ethyl 3-((S)-1,1-dimethylethylsulfinylamino)-4,4-difluoro-3-(2-fluorophenyl)butanoate

: 1448793-52-9
(R)-ethyl 3-((S)-1,1-dimethylethylsulfinylamino)-4,4-difluoro-3-(2-fluorophenyl)butanoate

Guidance literature:: ethyl bromoacetate; With copper(l) chloride; zinc; In tetrahydrofuran; at 55 ℃; for 0.5h; Inert atmosphere;

(S,Z)-N-(2,2-difluoro-1-(2-fluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide; at 0 - 5 ℃; for 1h;

Reference yield: 31.0%

: 1448793-52-9
(R)-ethyl 3-((S)-1,1-dimethylethylsulfinylamino)-4,4-difluoro-3-(2-fluorophenyl)butanoate

: 1448793-53-0
(S)-N-((S)-1,1-difluoro-2-(2-fluorophenyl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: (R)-ethyl 3-((S)-1,1-dimethylethylsulfinylamino)-4,4-difluoro-3-(2-fluorophenyl)butanoate; With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 - -72 ℃; for 0.5h; Inert atmosphere;

With water; ammonium chloride; In dichloromethane; ⁽²⁾H₈-toluene; at -78 - 20 ℃; for 0.5h;

Reference yield:

: 1448793-52-9
(R)-ethyl 3-((S)-1,1-dimethylethylsulfinylamino)-4,4-difluoro-3-(2-fluorophenyl)butanoate

: 1448793-56-3
(2S,4S)-4-amino-1,1,1,5,5-pentafluoro-4-(2-fluorophenyl)pentan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.5 h / -78 - -72 °C / Inert atmosphere

1.2: 0.5 h / -78 - 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Molecular sieve; Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 25 °C / Inert atmosphere

With hydrogenchloride; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;