(S)-2-methyl-N-((2S,4R)-1,1,5,5, 5-pentafluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinylamide

Base Information

Chemical Name:(S)-2-methyl-N-((2S,4R)-1,1,5,5, 5-pentafluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinylamide
CAS No.:1448793-54-1
Molecular Formula:C₁₅H₁₉F₆NO₂S
Molecular Weight:391.378
Hs Code.:

Synonyms:(S)-2-methyl-N-((2S,4R)-1,1,5,5, 5-pentafluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinylamide

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Chemical Property of (S)-2-methyl-N-((2S,4R)-1,1,5,5, 5-pentafluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinylamide

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Technology Process of (S)-2-methyl-N-((2S,4R)-1,1,5,5, 5-pentafluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinylamide

There total 5 articles about (S)-2-methyl-N-((2S,4R)-1,1,5,5, 5-pentafluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1448793-53-0
(S)-N-((S)-1,1-difluoro-2-(2-fluorophenyl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1448793-54-1
(S)-2-methyl-N-((2S,4R)-1,1,5,5, 5-pentafluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinylamide

: 1448793-55-2
(S)-2-methyl-N-((2S,4S)-1,1,5,5,5-pentafluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinamide

: C₁₈H₂₇F₆NO₂SSi

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; Molecular sieve; Inert atmosphere;

Reference yield:

: 124004-75-7
α,α,α-trifluoro-2-fluoroacetophenone

: 1448793-54-1
(S)-2-methyl-N-((2S,4R)-1,1,5,5, 5-pentafluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium; chloro-trimethyl-silane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 0.38 h / 20 °C / Cooling with ice

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Reflux

3.1: copper(l) chloride; zinc / tetrahydrofuran / 0.5 h / 55 °C / Inert atmosphere

3.2: 1 h / 0 - 5 °C

4.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.5 h / -78 - -72 °C / Inert atmosphere

4.2: 0.5 h / -78 - 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Molecular sieve; Inert atmosphere

With titanium(IV) tetraethanolate; chloro-trimethyl-silane; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; magnesium; copper(l) chloride; zinc; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1448793-50-7
(S,Z)-N-(2,2-difluoro-1-(2-fluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1448793-54-1
(S)-2-methyl-N-((2S,4R)-1,1,5,5, 5-pentafluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) chloride; zinc / tetrahydrofuran / 0.5 h / 55 °C / Inert atmosphere

1.2: 1 h / 0 - 5 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.5 h / -78 - -72 °C / Inert atmosphere

2.2: 0.5 h / -78 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Molecular sieve; Inert atmosphere

With tetrabutyl ammonium fluoride; diisobutylaluminium hydride; copper(l) chloride; zinc; In tetrahydrofuran; dichloromethane; toluene;