(2S,5S,8S,11S)-1,4,7-tribenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane

Base Information

• Chemical Name: (2S,5S,8S,11S)-1,4,7-tribenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane
• CAS No.: 1160293-93-5
• Molecular Formula: C₆₁H₇₀N₄O₄
• Molecular Weight: 923.251
• Mol file: 1160293-93-5.mol

Synonyms:(2S,5S,8S,11S)-1,4,7-tribenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane

Chemical Property of (2S,5S,8S,11S)-1,4,7-tribenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,5S,8S,11S)-1,4,7-tribenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane

There total 1 articles about (2S,5S,8S,11S)-1,4,7-tribenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(2S,5S,8S,11S)-1,4,7-tribenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-10-(2-nitrobenzenesulfonyl)-1,4,7,10-tetraazacyclododecane (1160293-91-3) → (2S,5S,8S,11S)-1,4,7-tribenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane (1160293-93-5)

Guidance literature:

With caesium carbonate; thiophenol; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/ol9005954

Reference yield: 83.0%

(2S,5S,8S,11S)-1,4,7-tribenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane (1160293-93-5) + benzyl bromide (100-39-0) → (2S,5S,8S,11S)-1,4,7,10-tetrabenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane (1160293-95-7)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; caesium carbonate; In N,N-dimethyl-formamide; at 0 ℃; Reflux;

DOI:10.1021/ol9005954

upstream raw materials:

(2S,5S,8S,11S)-1,4,7-tribenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-10-(2-nitrobenzenesulfonyl)-1,4,7,10-tetraazacyclododecane

Downstream raw materials:

(2S,5S,8S,11S)-1,4,7,10-tetrabenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane