(2S,5S,8S,11S)-1,4,7,10-tetrabenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane

Base Information

Chemical Name:(2S,5S,8S,11S)-1,4,7,10-tetrabenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane
CAS No.:1160293-95-7
Molecular Formula:C₆₈H₇₆N₄O₄
Molecular Weight:1013.38
Hs Code.:

Synonyms:(2S,5S,8S,11S)-1,4,7,10-tetrabenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane

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Chemical Property of (2S,5S,8S,11S)-1,4,7,10-tetrabenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane

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Technology Process of (2S,5S,8S,11S)-1,4,7,10-tetrabenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane

There total 8 articles about (2S,5S,8S,11S)-1,4,7,10-tetrabenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1160293-93-5
(2S,5S,8S,11S)-1,4,7-tribenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane

: 100-39-0
benzyl bromide

: 1160293-95-7
(2S,5S,8S,11S)-1,4,7,10-tetrabenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane

Guidance literature:: With tetra-(n-butyl)ammonium iodide; caesium carbonate; In N,N-dimethyl-formamide; at 0 ℃; Reflux;
DOI:10.1021/ol9005954

Reference yield: 70.0%

: (S)-1-benzyl-2-(4-methoxybenzyl)aziridine

: 1160293-95-7
(2S,5S,8S,11S)-1,4,7,10-tetrabenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane

Guidance literature:: With toluene-4-sulfonic acid; In acetonitrile; at 20 ℃; for 48h;
DOI:10.1021/acs.inorgchem.9b01799

Reference yield:

: (S)-2-(benzylamino)-3-(4-methoxyphenyl)propan-1-ol

: 1160293-95-7
(2S,5S,8S,11S)-1,4,7,10-tetrabenzyl-2,5,8,11-tetrakis-(4-methoxybenzyl)-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

2: toluene-4-sulfonic acid / acetonitrile / 96 h / 20 °C

With toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; acetonitrile;