5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-2-methyl-pyridine

Base Information

• Chemical Name: 5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-2-methyl-pyridine
• CAS No.: 1040376-44-0
• Molecular Formula: C₁₄H₁₁BrCl₂FNO
• Molecular Weight: 379.056
• Mol file: 1040376-44-0.mol

Synonyms:5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-2-methyl-pyridine

Chemical Property of 5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-2-methyl-pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-2-methyl-pyridine

There total 1 articles about 5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-2-methyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

C14H13Cl2FN2O (1040376-48-4) → 5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-2-methyl-pyridine (1040376-44-0)

Guidance literature:

C₁₄H₁₃Cl₂FN₂O; With hydrogen bromide; copper; copper(I) bromide; sodium nitrite; In water; at 0 - 20 ℃; for 4h;

With sodium hydroxide; In water; pH=7;

Reference yield: 94.0%

5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-2-methyl-pyridine (1040376-44-0) + tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate (375853-82-0,286961-14-6) → C24H27Cl2FN2O3 (1040377-22-7)

Guidance literature:

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 80 ℃;

Reference yield: 74.0%

2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethanol (1040377-08-9) + 5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-2-methyl-pyridine (1040376-44-0) → 2-(4-{5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-6-methyl-pyridin-3-yl}-pyrazol-1-yl)-ethanol (1040376-73-5)

Guidance literature:

2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethanol; 5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-2-methyl-pyridine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; for 0.166667h;

With sodium carbonate; In water; N,N-dimethyl-formamide; at 80 ℃;

upstream raw materials:

C₁₄H₁₃Cl₂FN₂O

Downstream raw materials:

C₂₄H₂₇Cl₂FN₂O₃

5-{5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-6-methyl-pyridin-3-yl}-1,3-dihydro-indol-2-one

3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[1-(2-methoxy-ethyl)-1H-pyrazol-4-yl]-2-methyl-pyridine

2-(4-{5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-6-methyl-pyridin-3-yl}-pyrazol-1-yl)-ethanol