1040377-08-9

Basic information

• Product Name: 1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester
• Synonyms: 1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester;1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester;2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethan-1-ol, 1-Hydroxy-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethane;2-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethanol;4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-ethanol;2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethan-1-ol;2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethan-1-ol;2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrazol-1-yl]ethanol
• CAS NO: 1040377-08-9
• Molecular Formula: C₁₁H₁₉BN₂O₃
• Molecular Weight: 238.09116
• Mol File: 1040377-08-9.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 379.4±22.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 14.47±0.10(Predicted)
• CAS DataBase Reference: 1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester(1040377-08-9)
• EPA Substance Registry System: 1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester(1040377-08-9)

Safety Data

• Hazardous Substances Data: 1040377-08-9(Hazardous Substances Data)

Usage

Uses

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-ethanol, can be used in the synthesis of series of aminopyridines with substituted benzoxazoles, acting c-Met kinase inhibitors.

Upstream product

• 269410-08-4 pyrazole-4-boronic acid pinacol ester 
• 540-51-2 2-bromoethanol 
• 214614-81-0 2-(4-bromo-1H-pyrazol-1-yl)ethan-1-ol 
• 73183-34-3 bis(pinacol)diborane 
• 96-49-1 [1,3]-dioxolan-2-one 

Downstream Products

• 1040376-73-5 2-(4-{5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-6-methyl-pyridin-3-yl}-pyrazol-1-yl)-ethanol 
• 1227939-87-8 2-(4-(4-amino-3-(4-aminophenyl)thieno[3,2-c]pyridin-7-yl)-1H-pyrazol-1-yl)ethanol 
• 1339891-02-9 1-(2-(4-methylpiperazin-1-yl)ethyl)-1H-pyrazol-4-ylboronic acid 
• 1392419-83-8 1-(2-(4-methylpiperazin-1-yl)ethyl)pyrazole-4-boronic acid pinacol ester 

Relevant articles and documents

NEW FYN AND VEGFR2 KINASE INHIBITORS

The invention relates to a N-phenylcarbamoyl compound of Formula (I) or a pharmaceutically acceptable salt thereof for use in the inhibition of at least one of tyrosine kinase selected from Fyn and VEGFR2 in the treatment of diseases and disorders involved with one or both kinases. (Formula)

FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY

A compound of formula (I): which inhibits the activity of one or more KATs of the MYST family, i.e., TIP60, KAT6B, MOZ, HBO1 and MOF.

NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF

The present invention relates to a naphthylamide compound of the structure as represented by formula (I), medicinal salts, prodrugs and hydrates or solvates thereof, and also relates to a method of preparing the compounds, pharmaceutical compositions comp