cis-1-p-Methoxyphenyl-3-isopropenyl-4-ethoxycarbonylazetidinone

Base Information

• Chemical Name: cis-1-p-Methoxyphenyl-3-isopropenyl-4-ethoxycarbonylazetidinone
• CAS No.: 124156-25-8
• Molecular Formula: C₁₆H₁₉NO₄
• Molecular Weight: 289.331
• Mol file: 124156-25-8.mol

Synonyms:cis-1-p-Methoxyphenyl-3-isopropenyl-4-ethoxycarbonylazetidinone

Chemical Property of cis-1-p-Methoxyphenyl-3-isopropenyl-4-ethoxycarbonylazetidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-1-p-Methoxyphenyl-3-isopropenyl-4-ethoxycarbonylazetidinone

There total 5 articles about cis-1-p-Methoxyphenyl-3-isopropenyl-4-ethoxycarbonylazetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3,3-Dimethylacryloyl chloride (3350-78-5) + ethyl (4-methoxyphenylimino)acetate (124156-21-4) → cis-1-p-Methoxyphenyl-3-isopropenyl-4-ethoxycarbonylazetidinone (124156-25-8)

Guidance literature:

With triethylamine; In dichloromethane; Heating;

DOI:10.1021/jo00289a035

Reference yield:

4-methoxy-aniline (104-94-9) → cis-1-p-Methoxyphenyl-3-isopropenyl-4-ethoxycarbonylazetidinone (124156-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium sulfate / CH₂Cl₂ / 2 h / 0 °C

2: NEt₃ / CH₂Cl₂ / Heating

With sodium sulfate; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4020(01)82006-8

Reference yield:

4-methoxy-aniline (104-94-9) → trans-1-p-Methoxyphenyl-3-isopropenyl-4-ethoxycarbonylazetidinone (124156-25-8,128537-73-5,128537-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium sulfate / CH₂Cl₂ / 2 h / 0 °C

2: NEt₃ / CH₂Cl₂ / Heating

With sodium sulfate; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4020(01)82006-8

upstream raw materials:

3,3-Dimethylacryloyl chloride

ethyl (4-methoxyphenylimino)acetate

4-methoxy-aniline

Downstream raw materials:

1-p-anisyl-3-isopropylidene-4-carbethoxy-2-azetidinone

cis-1-p-anisyl-3-isopropyl-4-carbethoxy-2-azetidinone

3-isopropyl-4-acetoxy-2-azetidinone

1-p-anisyl-3-isopropylidene-4-carboxy-2-azetidinone