(9bRS,12aRS)-1,4,5,12a-tetrahydro-7,8-dimethoxy-12-phenyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinoline

Base Information

• Chemical Name: (9bRS,12aRS)-1,4,5,12a-tetrahydro-7,8-dimethoxy-12-phenyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinoline
• CAS No.: 133964-05-3
• Molecular Formula: C₂₁H₂₂N₂O₃
• Molecular Weight: 350.417

Synonyms:(9bRS,12aRS)-1,4,5,12a-tetrahydro-7,8-dimethoxy-12-phenyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinoline

Chemical Property of (9bRS,12aRS)-1,4,5,12a-tetrahydro-7,8-dimethoxy-12-phenyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinoline

Chemical Property:

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Technology Process of (9bRS,12aRS)-1,4,5,12a-tetrahydro-7,8-dimethoxy-12-phenyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinoline

There total 1 articles about (9bRS,12aRS)-1,4,5,12a-tetrahydro-7,8-dimethoxy-12-phenyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolinium; bromide (123420-50-8) + benzohydroximoyl chloride (698-16-8) → (9bRS,12aRS)-1,4,5,12a-tetrahydro-7,8-dimethoxy-12-phenyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinoline (133964-05-3)

Guidance literature:

With triethylamine; In chloroform; 1) ice bath, 0.5 h, 2) 25 deg C, 1 h;

DOI:10.1021/jo00015a025

Reference yield: 94.0%

(9bRS,12aRS)-1,4,5,12a-tetrahydro-7,8-dimethoxy-12-phenyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinoline (133964-05-3) + methyl iodide (74-88-4) → (3RS,9bRS,12aRS)-1,4,5,12a-tetrahydro-7,8-dimethoxy-3-methyl-12-phenyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinolinium iodide (133964-06-4)

Guidance literature:

for 8h; Heating;

DOI:10.1021/jo00015a025

Reference yield: 77.0%

benzyl bromide (100-39-0) + (9bRS,12aRS)-1,4,5,12a-tetrahydro-7,8-dimethoxy-12-phenyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinoline (133964-05-3) → 6-Benzyl-10,11-dimethoxy-3-phenyl-5,6,7,8-tetrahydro-4H-1-oxa-2,6-diaza-benzo[a]cyclopenta[c]cyclononene; hydrobromide (133910-75-5)

Guidance literature:

at 100 ℃; for 2h;

DOI:10.1021/jo00015a025

upstream raw materials:

8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolinium; bromide

benzohydroximoyl chloride

Downstream raw materials:

6-Benzyl-10,11-dimethoxy-3-phenyl-5,6,7,8-tetrahydro-4H-1-oxa-2,6-diaza-benzo[a]cyclopenta[c]cyclononene; hydrobromide

(3RS,9bRS,12aRS)-1,4,5,12a-tetrahydro-7,8-dimethoxy-3-methyl-12-phenyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinolinium iodide

5,6,7,8-tetrahydro-10,11-dimethoxy-6-methyl-3-phenyl-4H-isoxazolo<4,5-f><3>benzazonine

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