(2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid ((Z)-2-hydroxy-1-trimethylsilanyl-6-trityloxy-hex-4-enyl)-amide

Base Information

Chemical Name:(2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid ((Z)-2-hydroxy-1-trimethylsilanyl-6-trityloxy-hex-4-enyl)-amide
CAS No.:596818-23-4
Molecular Formula:C₅₀H₆₃NO₅Si
Molecular Weight:786.139
Hs Code.:

(2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid ((Z)-2-hydroxy-1-trimethylsilanyl-6-trityloxy-hex-4-enyl)-amide

Synonyms:(2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid ((Z)-2-hydroxy-1-trimethylsilanyl-6-trityloxy-hex-4-enyl)-amide

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Chemical Property of (2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid ((Z)-2-hydroxy-1-trimethylsilanyl-6-trityloxy-hex-4-enyl)-amide

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Technology Process of (2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid ((Z)-2-hydroxy-1-trimethylsilanyl-6-trityloxy-hex-4-enyl)-amide

There total 9 articles about (2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid ((Z)-2-hydroxy-1-trimethylsilanyl-6-trityloxy-hex-4-enyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71321-16-9
3-(trimethylsilyl)prop-2-yn-1-yl 4-methylbenzenesulfonate

: 596818-23-4
(2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid ((Z)-2-hydroxy-1-trimethylsilanyl-6-trityloxy-hex-4-enyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1: 76 percent / NaI; K₂CO₃ / dimethylformamide / 12 h / 20 °C

2: 53 percent / H₂; NaBH₄; (CH₂NH₂)2 / Ni(OAc)2*4H₂O / ethanol / 8 h / 20 °C

3: 82 percent / Et₃N; DMAP / CH₂Cl₂ / 12 h / 0 - 20 °C

4: 55 percent / mCPBA / CH₂Cl₂ / 2 h / 0 - 20 °C

5: 78 percent / NaN₃; NH₄Cl / methanol; H₂O / 15 h / 0 - 20 °C

6: LiAlH₄ / diethyl ether / 2 h / 0 - 20 °C

7: CH₂Cl₂ / 12 h

With dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; hydrogen; potassium carbonate; ammonium chloride; ethylenediamine; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; nickel diacetate; In methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)01171-7

Reference yield:

: 5272-36-6
3-trimethylsilyl-2-propyn-1-ol

: 596818-23-4
(2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid ((Z)-2-hydroxy-1-trimethylsilanyl-6-trityloxy-hex-4-enyl)-amide

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 0 - 20 °C

2: 76 percent / NaI; K₂CO₃ / dimethylformamide / 12 h / 20 °C

3: 53 percent / H₂; NaBH₄; (CH₂NH₂)2 / Ni(OAc)2*4H₂O / ethanol / 8 h / 20 °C

4: 82 percent / Et₃N; DMAP / CH₂Cl₂ / 12 h / 0 - 20 °C

5: 55 percent / mCPBA / CH₂Cl₂ / 2 h / 0 - 20 °C

6: 78 percent / NaN₃; NH₄Cl / methanol; H₂O / 15 h / 0 - 20 °C

7: LiAlH₄ / diethyl ether / 2 h / 0 - 20 °C

8: CH₂Cl₂ / 12 h

With dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; hydrogen; potassium carbonate; ammonium chloride; ethylenediamine; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; nickel diacetate; In methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)01171-7

Reference yield:

: 144889-69-0
6-(trimethylsilyl)hexa-2,5-diyn-1-ol

: 596818-23-4
(2E,4E,10E)-(6S,7S,8R,9S)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoic acid ((Z)-2-hydroxy-1-trimethylsilanyl-6-trityloxy-hex-4-enyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 53 percent / H₂; NaBH₄; (CH₂NH₂)2 / Ni(OAc)2*4H₂O / ethanol / 8 h / 20 °C

2: 82 percent / Et₃N; DMAP / CH₂Cl₂ / 12 h / 0 - 20 °C

3: 55 percent / mCPBA / CH₂Cl₂ / 2 h / 0 - 20 °C

4: 78 percent / NaN₃; NH₄Cl / methanol; H₂O / 15 h / 0 - 20 °C

5: LiAlH₄ / diethyl ether / 2 h / 0 - 20 °C

6: CH₂Cl₂ / 12 h

With dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; hydrogen; ammonium chloride; ethylenediamine; triethylamine; 3-chloro-benzenecarboperoxoic acid; nickel diacetate; In methanol; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1016/S0040-4039(03)01171-7