2'-chloro-4'-[(2S,3S,4S)-4-ethyl-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile

Base Information

Chemical Name:2'-chloro-4'-[(2S,3S,4S)-4-ethyl-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile
CAS No.:1114545-77-5
Molecular Formula:C₁₄H₁₅ClN₂O₂
Molecular Weight:278.738
Hs Code.:

Synonyms:2'-chloro-4'-[(2S,3S,4S)-4-ethyl-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile

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Chemical Property of 2'-chloro-4'-[(2S,3S,4S)-4-ethyl-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile

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Technology Process of 2'-chloro-4'-[(2S,3S,4S)-4-ethyl-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile

There total 3 articles about 2'-chloro-4'-[(2S,3S,4S)-4-ethyl-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1114545-61-7
2'-chloro-4'-[(2S,3S)-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile

: 75-03-6
ethyl iodide

: 1114545-77-5
2'-chloro-4'-[(2S,3S,4S)-4-ethyl-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

2'-chloro-4'-[(2S,3S)-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

ethyl iodide; In tetrahydrofuran; hexane; at -78 - -30 ℃; for 1h;

Reference yield:

: 1114546-47-2
(2S,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-methylpyrrolidin-5-one

: 1114545-77-5
2'-chloro-4'-[(2S,3S,4S)-4-ethyl-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C

2.2: 1 h / -78 - -30 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; caesium carbonate; diisopropylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; hexane; 1.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2017.04.018

Reference yield:

: 151004-19-2
(4S,5S)-5-methyl-4-hydroxy-2-oxopyrrolidine

: 1114545-77-5
2'-chloro-4'-[(2S,3S,4S)-4-ethyl-3-hydroxy-2-methyl-5-oxopyrrolidin-1-yl]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / 18 h / 0 - 20 °C

2.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C

3.2: 1 h / -78 - -30 °C

With 1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; caesium carbonate; diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; hexane; 2.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2017.04.018