benzyl 4-(4-allyloxyphenyl)-3-hydroxy-5-triisopropylsilanyloxypiperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-(4-allyloxyphenyl)-3-hydroxy-5-triisopropylsilanyloxypiperidine-1-carboxylate
CAS No.:911210-37-2
Molecular Formula:C₃₁H₄₅NO₅Si
Molecular Weight:539.788
Hs Code.:

Synonyms:benzyl 4-(4-allyloxyphenyl)-3-hydroxy-5-triisopropylsilanyloxypiperidine-1-carboxylate

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Chemical Property of benzyl 4-(4-allyloxyphenyl)-3-hydroxy-5-triisopropylsilanyloxypiperidine-1-carboxylate

Chemical Property:

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Technology Process of benzyl 4-(4-allyloxyphenyl)-3-hydroxy-5-triisopropylsilanyloxypiperidine-1-carboxylate

There total 6 articles about benzyl 4-(4-allyloxyphenyl)-3-hydroxy-5-triisopropylsilanyloxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911210-38-3
benzyl 3-hydroxy-4-(4-hydroxyphenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate

: 106-95-6
allyl bromide

: 911210-37-2
benzyl 4-(4-allyloxyphenyl)-3-hydroxy-5-triisopropylsilanyloxypiperidine-1-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 24h;

Reference yield:

: 257928-45-3
4-(4-benzyloxyphenyl)-1-(1-phenylethyl)-1,2,3,4-tetrahydro-pyridin-3-ol

: 911210-37-2
benzyl 4-(4-allyloxyphenyl)-3-hydroxy-5-triisopropylsilanyloxypiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C

2.1: borane-THF / tetrahydrofuran; 1,2-dimethoxyethane / 3 h / 0 - 30 °C

2.2: 0.08 h / 20 °C

2.3: 1 h / 50 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 8 h / 20 °C

4.1: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h

5.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 70 °C

With 2,6-dimethylpyridine; borane-THF; hydrogen; sodium hydrogencarbonate; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 911210-41-8
4-(4-Benzyloxyphenyl)-1-(1-phenylethyl)-3-triisopropylsilanyloxy-1,2,3,4-tetrahydro-pyridine

: 911210-37-2
benzyl 4-(4-allyloxyphenyl)-3-hydroxy-5-triisopropylsilanyloxypiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran; 1,2-dimethoxyethane / 3 h / 0 - 30 °C

1.2: 0.08 h / 20 °C

1.3: 1 h / 50 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 8 h / 20 °C

3.1: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h

4.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 70 °C

With borane-THF; hydrogen; sodium hydrogencarbonate; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide;