2-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]-N-ethylisoindoline-1-carboxamide

Base Information

Chemical Name:2-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]-N-ethylisoindoline-1-carboxamide
CAS No.:914298-99-0
Molecular Formula:C₂₂H₂₅ClN₂O₆
Molecular Weight:448.903
Hs Code.:

Synonyms:2-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]-N-ethylisoindoline-1-carboxamide

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Chemical Property of 2-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]-N-ethylisoindoline-1-carboxamide

Chemical Property:

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Technology Process of 2-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]-N-ethylisoindoline-1-carboxamide

There total 6 articles about 2-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]-N-ethylisoindoline-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.7%

: N-ethylisoindoline-1-carboxamide

: 914298-26-3
5-chloro-2,4-bis(methoxymethoxy)benzoic acid

: 914298-99-0
2-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]-N-ethylisoindoline-1-carboxamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 914298-27-4
2-(5-chloro-2,4-bis-methoxymethoxybenzoyl)-2,3-dihydro-1H-isoindole-1-carboxylic acid

: 75-04-7,85404-22-4
ethylamine

: 914298-99-0
2-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]-N-ethylisoindoline-1-carboxamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 23 ℃; for 12h;
DOI:10.1021/jm901209q

Reference yield:

: 914298-92-3
methyl 2,4-dimethoxymethyloxybenzoate

: 914298-99-0
2-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]-N-ethylisoindoline-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: calcium hypochlorite / acetic acid; acetone / 12 h / 20 °C

2.1: methanol; sodium hydroxide; water / 12 h / 20 °C

2.2: pH 6.5

3.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

With 4-methyl-morpholine; methanol; sodium hydroxide; calcium hypochlorite; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetic acid; N,N-dimethyl-formamide; acetone;