2-cyclopropyl-N'-(4-((((1S,2S)-2-(4-fluorophenyl)-cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)acetohydrazide

Base Information

Chemical Name:2-cyclopropyl-N'-(4-((((1S,2S)-2-(4-fluorophenyl)-cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)acetohydrazide
CAS No.:1455029-03-4
Molecular Formula:C₂₁H₂₂F₄N₄O
Molecular Weight:422.425
Hs Code.:

Synonyms:2-cyclopropyl-N'-(4-((((1S,2S)-2-(4-fluorophenyl)-cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)acetohydrazide

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Chemical Property of 2-cyclopropyl-N'-(4-((((1S,2S)-2-(4-fluorophenyl)-cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)acetohydrazide

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Technology Process of 2-cyclopropyl-N'-(4-((((1S,2S)-2-(4-fluorophenyl)-cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)acetohydrazide

There total 5 articles about 2-cyclopropyl-N'-(4-((((1S,2S)-2-(4-fluorophenyl)-cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54322-65-5
cyclopropylacetyl chloride

: 1455029-02-3
N-(((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methyl)-2-hydrazinyl-3-(trifluoromethyl)pyridin-4-amine

: 1455029-03-4
2-cyclopropyl-N'-(4-((((1S,2S)-2-(4-fluorophenyl)-cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)acetohydrazide

Guidance literature:: With sodium carbonate; In tetrahydrofuran; for 1h;

Reference yield:

: 1186194-98-8
2,4-dichloro-3-(trifluoromethyl)pyridine

: 1455029-03-4
2-cyclopropyl-N'-(4-((((1S,2S)-2-(4-fluorophenyl)-cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)acetohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; hydrogenchloride / acetonitrile; water / 6 h / Reflux; Inert atmosphere

2: hydrazine hydrate / 1,4-dioxane / 16 h / Reflux; Inert atmosphere

3: sodium carbonate / tetrahydrofuran / 1 h

With hydrogenchloride; sodium carbonate; hydrazine hydrate; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;

Reference yield:

: 1455582-66-7,372184-05-9
((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methanamine

: 1455029-03-4
2-cyclopropyl-N'-(4-((((1S,2S)-2-(4-fluorophenyl)-cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)acetohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; hydrogenchloride / acetonitrile; water / 6 h / Reflux; Inert atmosphere

2: hydrazine hydrate / 1,4-dioxane / 16 h / Reflux; Inert atmosphere

3: sodium carbonate / tetrahydrofuran / 1 h

With hydrogenchloride; sodium carbonate; hydrazine hydrate; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;