54322-65-5

Basic information

• Product Name: Cyclopropylacetyl chloride
• Synonyms: Cyclopropylacetyl chloride;cyclopropylacetic acid chloride
• CAS NO: 54322-65-5
• Molecular Formula: C₅H₇ClO
• Molecular Weight: 118.56148
• Mol File: 54322-65-5.mol
• Article Data: 42

Chemical Properties

• Boiling Point: 135.8±9.0 °C(Predicted)
• Appearance: /
• Density: 1.193±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Cyclopropylacetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropylacetyl chloride(54322-65-5)
• EPA Substance Registry System: Cyclopropylacetyl chloride(54322-65-5)

Safety Data

• Hazardous Substances Data: 54322-65-5(Hazardous Substances Data)

Usage

General Description

Cyclopropylacetyl chloride is a chemical compound with the molecular formula C5H7ClO. It is a colorless to light yellow liquid with a pungent odor, and it is highly reactive and flammable. It is primarily used as a reagent in organic synthesis to introduce the cyclopropylacetyl group into various organic molecules. It is also employed in the production of pharmaceuticals and agrochemicals, as well as in the synthesis of other specialty chemicals. Due to its reactivity and potential hazards, proper safety precautions, including the use of personal protective equipment and proper ventilation, must be observed when handling and using cyclopropylacetyl chloride.

Upstream product

• 6542-60-5 2-cyclopropylacetonitrile 
• 2516-33-8 Cyclopropylmethanol 
• 143-33-9 sodium cyanide 
• 5239-82-7 cyclopropylacetic acid 

Downstream Products

• 34108-21-9 methyl cyclopropylacetate 
• 1154385-73-5 cyclopropylthioacetamide 
• 1202158-67-5 C₃₂H₃₉N₇O 
• 437603-06-0 2-(cyclopropylmethyl)-1-(2-phenoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine 
• 59698-21-4 5-cyclopropyl-2-thio-2,3-dihydropyrimidine-2,4(1H,3H)-dione 
• 59698-20-3 5-cyclopropyl-pyrimidin-2,4-(1H,3H)-dione 
• 125303-02-8 N-Methyl-N-phenylcyclopropylacetamide 
• 70458-22-9 3-chlorobenzoic 2-cyclopropylacetic peroxyanhydride 
• 5687-69-4 2-cyclopropyl-N-phenylacetamide 
• 5618-03-1 3-cyclopropanepropionic acid 
• 1017933-24-2 (2S)-2-benzyloxycarbonylamino-4-oxo-5-cyclopropylpentanoic acid methyl ester 
• 1254981-29-7 N'-[4-(benzyloxy)-3-(trifluoromethyl)pyridin-2-yl]-2-cyclopropylacetohydrazide 
• 1068601-77-3 2-cyclopropyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylacetamide 
• 1006602-15-8 C₁₂H₁₃NO₄ 

Relevant articles and documents

Identification of cyclopropylacetyl-(r)-carnitine, a unique chemical marker of the fatally toxic mushroom russula subnigricans

A toxic mushroom, Russula subnigricans, causes fatal poisoning by mistaken ingestion. In spite of the potent bioactivity, the responsible toxin had not been identified for about 50 years since its first documentation. Recently, we isolated an unstable toxin and determined the structure. The slow elucidation was partly due to the instability of the toxin and also due to misidentification of R. subnigricans for similar mushrooms. To discriminate genuine Russula subnigricans from similar unidentified Russula species, we searched for a unique chemical marker contained in the mushroom. Cyclopropylacetyl-(R)-carnitine specific to R. subnigricans was identified as a novel compound whose 1H-NMR signals appearing in the upfield region were easily recognizable among the complicated signals of the crude extract.

ANTI-OSTEOARTHRITIS HYDANTOIN COMPOUNDS AND RELATED COMPOSITIONS AND METHODS

This invention provides hydantoin compounds that inhibit both aggrecanase 1 (Adamts4) and aggrecanase 2 (Adamts5). This invention also provides related compositions and methods for treating inflammatory diseases, diseases involving degradation of cartilage, and diseases involving the disruption of cartilage homeostasis.

MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES

The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Decarboxylative Borylation of mCPBA-Activated Aliphatic Acids

A decarboxylative borylation of aliphatic acids for the synthesis of a variety of alkylboronates has been developed by mixing m-chloroperoxybenzoic acid (mCPBA)-activated fatty acids with bis(catecholato)diboron in N,N-dimethylformamide (DMF) at room temperature. A radical chain process is involved in the reaction which initiates from the B-B bond homolysis followed by the radical transfer from the boron atom to the carbon atom with subsequent decarboxylation and borylation.