5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(butoxy)benzoyl guanidine

Base Information

Chemical Name:5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(butoxy)benzoyl guanidine
CAS No.:1373428-21-7
Molecular Formula:C₂₈H₃₉N₅O₆
Molecular Weight:541.648
Hs Code.:

Synonyms:5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(butoxy)benzoyl guanidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(butoxy)benzoyl guanidine

Chemical Property:

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Technology Process of 5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(butoxy)benzoyl guanidine

There total 10 articles about 5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(butoxy)benzoyl guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.1%

: 1373428-12-6
5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(butoxy)benzoic acid

: 113-00-8
guanidine nitrate

: 1373428-21-7
5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(butoxy)benzoyl guanidine

: C₂₈H₃₇N₅O₇

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;
DOI:10.1002/cjoc.201180470

Reference yield:

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1373428-21-7
5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(butoxy)benzoyl guanidine

: C₂₈H₃₇N₅O₇

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 20 °C

2: potassium carbonate / methanol / 1 h / Reflux

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/cjoc.201180470

Reference yield:

: 1373428-27-3
C₂₃H₂₈N₂O₇

: 1373428-21-7
5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(butoxy)benzoyl guanidine

: C₂₈H₃₇N₅O₇

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride

2: potassium carbonate / acetonitrile / Reflux

3: potassium carbonate / methanol / 1 h / Reflux

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

With thionyl chloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/cjoc.201180470