3,4,6,7-tetra-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-D-glycero-D-ido-heptono-nitrile

Base Information

Chemical Name:3,4,6,7-tetra-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-D-glycero-D-ido-heptono-nitrile
CAS No.:884507-69-1
Molecular Formula:C₄₃H₄₄N₂O₇
Molecular Weight:700.832
Hs Code.:

Synonyms:3,4,6,7-tetra-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-D-glycero-D-ido-heptono-nitrile

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Chemical Property of 3,4,6,7-tetra-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-D-glycero-D-ido-heptono-nitrile

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Technology Process of 3,4,6,7-tetra-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-D-glycero-D-ido-heptono-nitrile

There total 1 articles about 3,4,6,7-tetra-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-D-glycero-D-ido-heptono-nitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1021325-68-7
N-benzyloxycarbonyl 2,3,5,6-tetra-O-benzyl-α,β-D-glucofuranosylamine

: 7677-24-9
trimethylsilyl cyanide

: 884507-69-1
3,4,6,7-tetra-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-D-glycero-D-ido-heptono-nitrile

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at -40 ℃; for 15h;
DOI:10.1021/ol053078z

Reference yield: 88.0%

: 884507-69-1
3,4,6,7-tetra-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-D-glycero-D-ido-heptono-nitrile

: 124-63-0
methanesulfonyl chloride

: 884507-73-7
3,4,6,7-tetra-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-5-O-methanesulfonyl-D-glycero-D-ido-heptononitrile

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1021/ol053078z

Reference yield:

: 884507-69-1
3,4,6,7-tetra-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-D-glycero-D-ido-heptono-nitrile

: 3,4,6,7-tetra-O-benzyl-2,5-dideoxy-2,5-imino-D-glycero-L-gluco-heptanonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / Et₃N / CH₂Cl₂ / 5 h / 20 °C

2: t-BuOK / tetrahydrofuran / 12 h / 20 °C

3: 99 percent / Et₃N; H₂ / Pd/C / ethanol / 3 h / 20 °C

With potassium tert-butylate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol053078z