(R)-N-ethyl-N-methylcarbamic acid-3-(1-hydroxyethyl)phenyl ester

Base Information

• Chemical Name: (R)-N-ethyl-N-methylcarbamic acid-3-(1-hydroxyethyl)phenyl ester
• CAS No.: 856408-80-5
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.272
• Mol file: 856408-80-5.mol

Synonyms:(R)-N-ethyl-N-methylcarbamic acid-3-(1-hydroxyethyl)phenyl ester

Chemical Property of (R)-N-ethyl-N-methylcarbamic acid-3-(1-hydroxyethyl)phenyl ester

Chemical Property:

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-N-ethyl-N-methylcarbamic acid-3-(1-hydroxyethyl)phenyl ester

There total 11 articles about (R)-N-ethyl-N-methylcarbamic acid-3-(1-hydroxyethyl)phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene (1222073-98-4) → (R)-N-ethyl-N-methylcarbamic acid-3-(1-hydroxyethyl)phenyl ester (856408-80-5)

Guidance literature:

With C₅₂H₆₇ClIrN₂P; potassium tert-butylate; hydrogen; In ethanol; at 50 ℃; for 9h; under 1500.15 - 75007.5 Torr; Reagent/catalyst; Solvent; Temperature; Autoclave;

Reference yield: 99.0%

1-(N-ethyl-N-methylaminocarbonyloxy)-3-acetylbenzene (855300-09-3) → (R)-N-ethyl-N-methylcarbamic acid-3-(1-hydroxyethyl)phenyl ester (856408-80-5)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; C₃₂H₃₉BrMnN₂O₂P; potassium tert-butylate; hydrogen; In methanol; at 20 ℃; for 16h; under 22502.3 Torr; enantioselective reaction; Glovebox; Autoclave;

DOI:10.1002/anie.201814751

Reference yield: 94.9%

phthalic acid mono-{1-[3-(ethylmethylcarbamoyloxy)phenyl]ethyl} ester (R)-1-phenylethylamine → (R)-N-ethyl-N-methylcarbamic acid-3-(1-hydroxyethyl)phenyl ester (856408-80-5)

Guidance literature:

phthalic acid mono-{1-[3-(ethylmethylcarbamoyloxy)phenyl]ethyl} ester (R)-1-phenylethylamine; With hydrogenchloride; In water; ethyl acetate; for 0.5h;

With water; sodium hydroxide; at 70 ℃; for 0.5h;

upstream raw materials:

1-(N-ethyl-N-methylaminocarbonyloxy)-3-acetylbenzene

(R)-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-acetoxyethyl) benzene

rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene

3-Hydroxyacetophenone

Downstream raw materials:

rivastigmin

C₁₃H₁₉NO₅S