rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene

Base Information

• Chemical Name: rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene
• CAS No.: 1222073-98-4
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.272
• Mol file: 1222073-98-4.mol

Synonyms:rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene

Chemical Property of rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene

There total 3 articles about rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(N-ethyl-N-methylaminocarbonyloxy)-3-acetylbenzene (855300-09-3) → rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene (1222073-98-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 1.75h; Cooling with ice;

DOI:10.1002/chem.201800588

Reference yield:

3-Hydroxyacetophenone (121-71-1) → rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene (1222073-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 3 h / Reflux

2: sodium tetrahydroborate / ethanol / 1 h / 0 - 20 °C

With sodium tetrahydroborate; potassium carbonate; In ethanol; acetone;

DOI:10.14233/ajchem.2013.13473

Reference yield:

rivastigmin (123441-03-2,415973-05-6) → 1-(N-ethyl-N-methylaminocarbonyloxy)-3-acetylbenzene (855300-09-3) + rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene (1222073-98-4)

Guidance literature:

With water; In acetonitrile; for 5h; UV-irradiation;

DOI:10.1016/j.jphotochem.2012.04.015

upstream raw materials:

1-(N-ethyl-N-methylaminocarbonyloxy)-3-acetylbenzene

rivastigmin

3-Hydroxyacetophenone

Downstream raw materials:

3-(1-bromoethyl)phenyl ethyl(methyl)carbamate

(R)-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-acetoxyethyl) benzene

(S)-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene

(R)-N-ethyl-N-methylcarbamic acid-3-(1-hydroxyethyl)phenyl ester