(S)-3-(ethylamino)-4-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methylamino)cyclobut-3-ene-1,2-dione

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Chemical Name:(S)-3-(ethylamino)-4-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methylamino)cyclobut-3-ene-1,2-dione
CAS No.:1308299-23-1
Molecular Formula:C₂₀H₂₃FN₄O₅
Molecular Weight:418.425
Hs Code.:

Synonyms:(S)-3-(ethylamino)-4-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methylamino)cyclobut-3-ene-1,2-dione

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Chemical Property of (S)-3-(ethylamino)-4-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methylamino)cyclobut-3-ene-1,2-dione

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Technology Process of (S)-3-(ethylamino)-4-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methylamino)cyclobut-3-ene-1,2-dione

There total 3 articles about (S)-3-(ethylamino)-4-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methylamino)cyclobut-3-ene-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1308299-21-9
(S)-3-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methylamino)-4-methoxycyclobut-3-ene-1,2-dione

: 75-04-7,85404-22-4
ethylamine

: 1308299-23-1
(S)-3-(ethylamino)-4-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: In tetrahydrofuran; methanol; dichloromethane; at 20 ℃; for 2h;
DOI:10.2174/157340611794072670

Reference yield:

: 168828-90-8
(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

: 1308299-23-1
(S)-3-(ethylamino)-4-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / methanol / 20 °C / pH 7.5

2: tetrahydrofuran; methanol; dichloromethane / 2 h / 20 °C

With triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.2174/157340611794072670

Reference yield:

: 168828-84-0
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one

: 1308299-23-1
(S)-3-(ethylamino)-4-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen; acetic acid / methanol / 2 h

2: triethylamine / methanol / 20 °C / pH 7.5

3: tetrahydrofuran; methanol; dichloromethane / 2 h / 20 °C

With palladium on activated charcoal; hydrogen; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.2174/157340611794072670