CYCLO(-D-LEU-D-PRO)

Base Information

• Chemical Name: CYCLO(-D-LEU-D-PRO)
• CAS No.: 274680-11-4
• Molecular Formula: C₁₁H₁₈N₂O₂
• Molecular Weight: 210.276
• Mol file: 274680-11-4.mol

Synonyms:3-(2-methylpropyl)hexahydropyrrolo[1,2-a]pyrazin-1,4-dione

Chemical Property of CYCLO(-D-LEU-D-PRO)

Chemical Property:

• Boiling Point: 427.6±34.0 °C(Predicted)
• PKA: 13.27±0.40(Predicted)
• Density: 1.14±0.1 g/cm3(Predicted)
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

Cyclo(-D-Leu-D-Pro) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of CYCLO(-D-LEU-D-PRO)

There total 2 articles about CYCLO(-D-LEU-D-PRO) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-prolyl-L-leucylglycylglycine (75188-89-5) → 3-(2-methylpropyl)hexahydropyrrolo[1,2-a]pyrazin-1,4-dione (274680-11-4) + D-prolyl-L-leucylglycylglycine (117760-62-0) + D-prolyl-D-leucylglycylglycine (75188-89-5,117760-62-0) + (3R,8aS)-hexahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione (36238-67-2) + (3S,8aR)-3-isobutyl-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione (2873-36-1,5654-86-4,19943-30-7,32510-93-3,36238-67-2,43041-29-8) + cyclo(L-Pro-L-Leu) (2873-36-1)

Guidance literature:

In various solvent(s); at 148.5 ℃; Product distribution; Rate constant; rate of racemization was investigated during decomposition;

Reference yield:

L-prolyl-L-leucine (52899-07-7) → 3-(2-methylpropyl)hexahydropyrrolo[1,2-a]pyrazin-1,4-dione (274680-11-4) + D-prolyl-L-leucine (52899-07-7) + L-prolyl-D-leucine (52899-07-7) + D-prolyl-D-leucine (52899-07-7) + (3R,8aS)-hexahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione (36238-67-2) + (3S,8aR)-3-isobutyl-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione (2873-36-1,5654-86-4,19943-30-7,32510-93-3,36238-67-2,43041-29-8)

Guidance literature:

In various solvent(s); at 148.5 ℃; Product distribution; Rate constant; rate of racemization was investigated;

Reference yield:

3-(2-methylpropyl)hexahydropyrrolo[1,2-a]pyrazin-1,4-dione (274680-11-4) → C11H22N2 (1261569-83-8,1072102-31-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Reflux;

DOI:10.1016/j.bmcl.2010.10.061

upstream raw materials:

L-prolyl-L-leucine

L-prolyl-L-leucylglycylglycine

Downstream raw materials:

C₁₁H₂₂N₂

Refernces