4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyltrifluoromethanesulfonate

Base Information

• Chemical Name: 4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyltrifluoromethanesulfonate
• CAS No.: 1448297-17-3
• Molecular Formula: C₂₀H₁₆F₃NO₇S
• Molecular Weight: 471.411
• Mol file: 1448297-17-3.mol

Synonyms:4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyltrifluoromethanesulfonate

Chemical Property of 4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyltrifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyltrifluoromethanesulfonate

There total 4 articles about 4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyltrifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran (141645-16-1) + trifluoromethylsulfonic anhydride (358-23-6) → 4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyltrifluoromethanesulfonate (1448297-17-3)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 3.16667h; Inert atmosphere;

DOI:10.24820/ark.5550190.p010.681

Reference yield:

2-(n-butyl)-5-nitrobenzofuran (133238-87-6) → 4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyltrifluoromethanesulfonate (1448297-17-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(IV) chloride / dichloromethane / 2.5 h / 0 - 20 °C

2: pyridine / dichloromethane / 3.17 h / 0 - 20 °C / Inert atmosphere

With pyridine; tin(IV) chloride; In dichloromethane; 1: |Friedel-Crafts Acylation;

DOI:10.24820/ark.5550190.p010.681

Reference yield:

Koshlands reagent I (772-33-8) → 4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyltrifluoromethanesulfonate (1448297-17-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triphenylphosphine / dichloromethane / 1 h / Reflux

1.2: 3 h / Reflux

2.1: tin(IV) chloride / dichloromethane / 2.5 h / 0 - 20 °C

3.1: pyridine / dichloromethane / 3.17 h / 0 - 20 °C / Inert atmosphere

With pyridine; tin(IV) chloride; triphenylphosphine; In dichloromethane; 2.1: |Friedel-Crafts Acylation;

DOI:10.24820/ark.5550190.p010.681

upstream raw materials:

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

trifluoromethylsulfonic anhydride

2-(n-butyl)-5-nitrobenzofuran

Koshlands reagent I

Downstream raw materials:

4-[(2-butyl-5-amino-1-benzofuran-3-yl)carbonyl]phenyltrifluoromethanesulfonate

4-({2-butyl-5-[(methylsulfonyl)amino]-1-benzofuran-3-yl}carbonyl)phenyltrifluoromethanesulfonate

dronedarone