(2R)-2-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline

Base Information

• Chemical Name: (2R)-2-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline
• CAS No.: 1239897-02-9
• Molecular Formula: C₂₆H₂₂N₂O₄
• Molecular Weight: 426.472
• Mol file: 1239897-02-9.mol

Synonyms:(2R)-2-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline

Chemical Property of (2R)-2-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline

There total 2 articles about (2R)-2-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(RS)-3-methyl-3,4-dihydro-2H-[1,4]benzoxazine (32329-20-7,113708-92-2) + phthaloyl-L-phenylalanyl chloride (32150-91-7) → (2R)-2-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline (1239897-02-9) + (2R)-2-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline (1239896-97-9) + (S)-2-methyl-1,2,3,4-tetrahydroquinoline (200125-70-8) + (R)-1,2,3,4-tetrahydroquinaldine (1780-19-4,63430-95-5,74497-74-8)

Guidance literature:

In acetonitrile; at -20 ℃; for 6h; optical yield given as %ee; stereoselective reaction;

DOI:10.1016/j.tetasy.2010.12.017

Reference yield:

(RS)-3-methyl-3,4-dihydro-2H-[1,4]benzoxazine (32329-20-7,113708-92-2) + phthaloyl-L-phenylalanyl chloride (32150-91-7) → (2R)-2-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline (1239897-02-9) + (2R)-2-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline (1239896-97-9) + (R)-3-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine + (S)-3-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

Guidance literature:

In acetonitrile; at 20 ℃; for 6h; optical yield given as %ee; stereoselective reaction;

DOI:10.1016/j.tetasy.2010.05.013

upstream raw materials:

(RS)-3-methyl-3,4-dihydro-2H-[1,4]benzoxazine

phthaloyl-L-phenylalanyl chloride