(RS)-2-(1-azidoethyl)-3-(t-butyldiphenylsiloxymethyl)-6-(dimethoxymethyl)pyridine

Base Information

Chemical Name:(RS)-2-(1-azidoethyl)-3-(t-butyldiphenylsiloxymethyl)-6-(dimethoxymethyl)pyridine
CAS No.:348128-67-6
Molecular Formula:C₂₇H₃₄N₄O₃Si
Molecular Weight:490.677
Hs Code.:

Synonyms:(RS)-2-(1-azidoethyl)-3-(t-butyldiphenylsiloxymethyl)-6-(dimethoxymethyl)pyridine

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Chemical Property of (RS)-2-(1-azidoethyl)-3-(t-butyldiphenylsiloxymethyl)-6-(dimethoxymethyl)pyridine

Chemical Property:

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Technology Process of (RS)-2-(1-azidoethyl)-3-(t-butyldiphenylsiloxymethyl)-6-(dimethoxymethyl)pyridine

There total 9 articles about (RS)-2-(1-azidoethyl)-3-(t-butyldiphenylsiloxymethyl)-6-(dimethoxymethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methanesulfonic acid 1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-6-dimethoxymethyl-pyridin-2-yl]-ethyl ester

: 348128-67-6
(RS)-2-(1-azidoethyl)-3-(t-butyldiphenylsiloxymethyl)-6-(dimethoxymethyl)pyridine

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide;
DOI:10.1246/cl.2001.380

Reference yield:

: 156459-19-7
3-cyano-6-(dimethoxymethyl)-2-pyridone

: 348128-67-6
(RS)-2-(1-azidoethyl)-3-(t-butyldiphenylsiloxymethyl)-6-(dimethoxymethyl)pyridine

Guidance literature:: Multi-step reaction with 9 steps

1: 6M KOH / ethanol / 8 h / Heating

2: 7.73 mg / p-toluenesulfonic acid hydrate / Heating

3: 81 percent / DMAP / pyridine / 0.5 h / 0 °C

4: Pd(OAc)2; dppp; Et₃N / toluene / 6 h / Heating

5: 1.28 g / 70 percent AcOH / tetrahydrofuran / 20 °C

6: 94 percent / CaCl₂; NaBH₄ / ethanol / 3.5 h / 0 - 20 °C

7: 86 percent / Et₃N; DMAP / CH₂Cl₂ / 2.5 h / 0 - 20 °C

8: Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

9: 0.42 g / NaN₃ / dimethylformamide / 0.5 h / 20 °C

With dmap; palladium diacetate; potassium hydroxide; sodium tetrahydroborate; sodium azide; 1,3-bis-(diphenylphosphino)propane; toluene-4-sulfonic acid; acetic acid; triethylamine; calcium chloride; In tetrahydrofuran; pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1246/bcsj.75.1583

Reference yield:

: 156459-20-0
6-(dimethoxymethyl)-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid

: 348128-67-6
(RS)-2-(1-azidoethyl)-3-(t-butyldiphenylsiloxymethyl)-6-(dimethoxymethyl)pyridine

Guidance literature:: Multi-step reaction with 8 steps

1: 7.73 mg / p-toluenesulfonic acid hydrate / Heating

2: 81 percent / DMAP / pyridine / 0.5 h / 0 °C

3: Pd(OAc)2; dppp; Et₃N / toluene / 6 h / Heating

4: 1.28 g / 70 percent AcOH / tetrahydrofuran / 20 °C

5: 94 percent / CaCl₂; NaBH₄ / ethanol / 3.5 h / 0 - 20 °C

6: 86 percent / Et₃N; DMAP / CH₂Cl₂ / 2.5 h / 0 - 20 °C

7: Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

8: 0.42 g / NaN₃ / dimethylformamide / 0.5 h / 20 °C

With dmap; palladium diacetate; sodium tetrahydroborate; sodium azide; 1,3-bis-(diphenylphosphino)propane; toluene-4-sulfonic acid; acetic acid; triethylamine; calcium chloride; In tetrahydrofuran; pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1246/bcsj.75.1583