156459-20-0

Usage

Uses

Used in Pharmaceutical Industry:
6-(dimethoxymethyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid is used as a pharmaceutical candidate for its potential antioxidant, anti-inflammatory, and analgesic properties. Its ability to modulate various biological pathways and alleviate symptoms of inflammation and pain makes it a valuable asset in the development of new drugs for treating various conditions.
Used in Drug Development:
6-(dimethoxymethyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid is used in drug development as a starting point for creating new therapeutic agents. Its unique structure and potential pharmacological effects provide a foundation for further research and optimization to enhance its efficacy and safety in treating specific diseases and conditions.
Further research is needed to fully elucidate the potential uses and mechanisms of action of 6-(dimethoxymethyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid, as well as to explore its potential synergistic effects when combined with other therapeutic agents. This will help in the development of more effective and targeted treatments for various medical conditions.

Upstream product

• 156459-19-7 3-cyano-6-(dimethoxymethyl)-2-pyridone 
• 6342-56-9 Pyruvic aldehyde dimethyl acetal 

Downstream Products

• 156459-21-1 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid 
• 348128-80-3 2-(1-tert-butoxycarbonylamino-ethyl)-6-{4-[1-tert-butoxycarbonyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylthiocarbamoyl]-thiazol-2-yl}-nicotinic acid benzyl ester 
• 348128-79-0 2-(1-tert-butoxycarbonylamino-ethyl)-6-{4-[1-tert-butoxycarbonyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-thiazol-2-yl}-nicotinic acid benzyl ester 
• 348128-73-4 phenacyl (RS)-2-[2-(1-t-butoxycarbonylaminoethyl)-3-(t-butyldiphenylsiloxymethyl)pyridin-6-yl]-1,3-thiazole-4-carboxylate 
• 348128-81-4 2-(1-tert-butoxycarbonylamino-ethyl)-6-[4-(1-tert-butoxycarbonyl-2-hydroxy-ethylthiocarbamoyl)-thiazol-2-yl]-nicotinic acid benzyl ester 
• 348128-82-5 2-(1-tert-butoxycarbonylamino-ethyl)-6-[4-(1-tert-butoxycarbonyl-2-hydroxy-ethylthiocarbamoyl)-thiazol-2-yl]-nicotinic acid benzyl ester 
• 348128-83-6 t-butyl (4S)-2-(2-{3-benzyloxycarbonyl-2-[(1R)-1-t-butoxycarbonylaminoethyl]pyridin-6-yl}-1,3-thiazol-4-yl)-4,5-dihydro-1,3-thiazole-4-carboxylate 
• 348128-85-8 t-butyl (4S)-2-(2-{3-benzyloxycarbonyl-2-[(1S)-1-t-butoxycarbonylaminoethyl]pyridin-6-yl}-1,3-thiazol-4-yl)-4,5-dihydro-1,3-thiazole-4-carboxylate 
• 348128-89-2 (R)-2'-[5-Benzyloxycarbonyl-6-((R)-1-tert-butoxycarbonylamino-ethyl)-pyridin-2-yl]-4,5-dihydro-[2,4']bithiazolyl-4-carboxylic acid 
• 348128-72-3 (RS)-2-[2-(1-t-butoxycarbonylaminoethyl)-3-(t-butyldiphenylsiloxymethyl)pyridin-6-yl]-1,3-thiazole-4-carboxylic acid 
• 348128-71-2 methyl (RS)-2-[2-(1-t-butoxycarbonylaminoethyl)-3-(t-butyldiphenylsiloxymethyl)pyridin-6-yl]-1,3-thiazole-4-carboxylate 
• 348128-74-5 phenacyl (RS)-2-[2-(1-t-butoxycarbonylaminoethyl)-3-(hydroxymethyl)pyridin-6-yl]-1,3-thiazole-4-carboxylate 
• 348128-69-8 (RS)-2-(1-t-butoxycarbonylaminoethyl)-3-(t-butyldiphenylsiloxymethyl)-6-(dimethoxymethyl)pyridine 
• 348128-75-6 phenacyl (RS)-2-(1H-2-t-butoxycarbonyl-1-oxo-2,3-dihydropyrrolo[3,4-b]pyridin-5-yl)-1,3-thiazole-4-carboxylate 

Relevant academic research and scientific papers

Novel synthesis of the main central 2,3,6-trisubstituted pyridine skeleton [Fragment A-B-C] of a macrobicyclic antibiotic, cyclothiazomycin

The useful synthesis of the main central 2,3,6-trisubstituted pyridine skeleton [the protected Fragment A-B-C] of a macrobicyclic antibiotic, cyclothiazomycin, was first accomplished. First, the 2-[2-(2-substituted thiazol-4-yl)]-4,5-dihydrothiazole-4-carboxylate [Fragment A derivative], attached to the 6-substituent of the main pyridine skeleton, was synthesized by two consecutive thiazolations of the protected Ser thioamide derivative with 3-bromopyruvate, and then thiazolination of the C-terminal Ser residue of the sequence. Secondly, an efficient synthesis of the central 2-(2-{2[(1R)-1-aminoethyl]pyridin-6-yl}thiazol-4-yl)-4, 5-dihydrothiazole-4-carboxylate [Fragment B derivative] was also achieved by thiazolation of the formyl group of the 2-(1-aminoethyl)-6-formylpyridine derivative, and then thiazolination. Thirdly, a convenient synthesis of the protected dehydrotetrapeptide [Fragment C derivative], which is bound to the 2-substituent of the pyridine skeleton, was attained by the usual stepwise elongation of the appropriate α-amino acids and β-elimination of a Thr residue of the sequence. Finally, the facile fragment condensation of the three Fragments thus obtained gave the protected Fragment A-B-C derivative via Fragment A-B. Furthermore, the configurational structures of the three Fragments (A, B, and C) were also investigated.

Convenient synthesis of a central 2,3,6-trisubstituted pyridine skeleton of a macrobicyclic antibiotic, cyclothiazomycin

The first convenient synthesis of the main central 2,3,6-trisubstituted pyridine skeleton [protected Fragment A-B] of a macrobicyclic antibiotic, cyclothiazomycin, was achieved.

An efficient synthesis of 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid and some carbonyl derivatives of it and its 6-acetyl homologue

Starting with 1,1-dimethoxy-2-propanone (1), 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid (5a) has been prepared in large quantities by a highly efficient, 4-step synthesis. This compound, along with its one carbon homologue, 6-acetyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid (5b) has been reacted with several carbonyl derivative forming reagents to provide a series of side chains for β-lactams. Among these carbonyl derivatives are styrylamides which were prepared from Wittig and Horner-Emmons reagents. The preparation of the phosphonium salts and phosphonate esters is also described.