(1-rS)-(Phenylsulfonyl)-3-methylene-(6-rR,9-rS)-bis(tert-butyldimethylsiloxy)spiro<4.4>nonane

Base Information

Chemical Name:(1-rS)-(Phenylsulfonyl)-3-methylene-(6-rR,9-rS)-bis(tert-butyldimethylsiloxy)spiro<4.4>nonane
CAS No.:123488-52-8
Molecular Formula:C₂₈H₄₈O₄SSi₂
Molecular Weight:536.924
Hs Code.:

Synonyms:(1-rS)-(Phenylsulfonyl)-3-methylene-(6-rR,9-rS)-bis(tert-butyldimethylsiloxy)spiro<4.4>nonane

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Chemical Property of (1-rS)-(Phenylsulfonyl)-3-methylene-(6-rR,9-rS)-bis(tert-butyldimethylsiloxy)spiro<4.4>nonane

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Technology Process of (1-rS)-(Phenylsulfonyl)-3-methylene-(6-rR,9-rS)-bis(tert-butyldimethylsiloxy)spiro<4.4>nonane

There total 13 articles about (1-rS)-(Phenylsulfonyl)-3-methylene-(6-rR,9-rS)-bis(tert-butyldimethylsiloxy)spiro<4.4>nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 72047-94-0
[2-(acetoxymethyl)prop-2-enyl]trimethylsilane

: 123487-86-5
[(2S,5R)-2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclopent-(Z)-ylidenemethanesulfonyl]-benzene

: 123488-52-8
(1-rS)-(Phenylsulfonyl)-3-methylene-(6-rR,9-rS)-bis(tert-butyldimethylsiloxy)spiro<4.4>nonane

Guidance literature:: With n-butyllithium; Pd⁽⁰⁾ complex from 10 molpercent palladium acetate and 60 molpercent triisopropylphosphite; In toluene; at 115 - 120 ℃; for 30h;
DOI:10.1016/S0040-4039(00)99500-5

Reference yield: 51.0%

: 72047-94-0
[2-(acetoxymethyl)prop-2-enyl]trimethylsilane

: 123487-86-5
2-<(Phenylsulfonyl)methylidene>cyclopentane-cis-1,3-diol silyl ether

: 123488-52-8
(1-rS)-(Phenylsulfonyl)-3-methylene-(6-rR,9-rS)-bis(tert-butyldimethylsiloxy)spiro<4.4>nonane

Guidance literature:: palladium diacetate; n-butyllithium; triisopropyl phosphite; In hexane; toluene; at 115 - 120 ℃; for 24h;
DOI:10.1021/ja00201a032

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 123488-52-8
(1-rS)-(Phenylsulfonyl)-3-methylene-(6-rR,9-rS)-bis(tert-butyldimethylsiloxy)spiro<4.4>nonane

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / imidazole, DMAP / dimethylformamide / 72 h / Ambient temperature

2: 51 percent / n-C₄H₉Li, Pd(OAc)2, (i-C₃H₇O)3P / hexane; toluene / 24 h / 115 - 120 °C

With 1H-imidazole; dmap; palladium diacetate; n-butyllithium; triisopropyl phosphite; In hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja00201a032