N-methoxy-2-(2-oxo-2-phenylethyl)-5-(trifluoromethyl)benzamide

Base Information

• Chemical Name: N-methoxy-2-(2-oxo-2-phenylethyl)-5-(trifluoromethyl)benzamide
• CAS No.: 1609939-65-2
• Molecular Formula: C₁₇H₁₄F₃NO₃
• Molecular Weight: 337.298
• Mol file: 1609939-65-2.mol

Synonyms:N-methoxy-2-(2-oxo-2-phenylethyl)-5-(trifluoromethyl)benzamide

Chemical Property of N-methoxy-2-(2-oxo-2-phenylethyl)-5-(trifluoromethyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-methoxy-2-(2-oxo-2-phenylethyl)-5-(trifluoromethyl)benzamide

There total 2 articles about N-methoxy-2-(2-oxo-2-phenylethyl)-5-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-styrenyloxytrimethylsilane (13735-81-4) + methyl N-methoxy-3-(trifluoromethyl)benzamide (1225463-01-3) → N-methoxy-2-(2-oxo-2-phenylethyl)-5-(trifluoromethyl)benzamide (1609939-65-2)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) acetate; In tetrahydrofuran; at 50 ℃; for 15h;

DOI:10.1021/acscatal.9b05622

Reference yield: 61.0%

methyl N-methoxy-3-(trifluoromethyl)benzamide (1225463-01-3) + mesyloxyacetophenone (20187-61-5) → N-methoxy-2-(2-oxo-2-phenylethyl)-5-(trifluoromethyl)benzamide (1609939-65-2) + 2-methoxy-3-phenyl-7-(trifluoromethyl)isoquinolin-1(2H)-one (1609939-36-7)

Guidance literature:

With tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate; sodium acetate; In methanol; at 60 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201310272

Reference yield:

N-methoxy-2-(2-oxo-2-phenylethyl)-5-(trifluoromethyl)benzamide (1609939-65-2) → 2-methoxy-3-phenyl-7-(trifluoromethyl)isoquinolin-1(2H)-one (1609939-36-7)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1002/anie.201310272

upstream raw materials:

methyl N-methoxy-3-(trifluoromethyl)benzamide

mesyloxyacetophenone

1-styrenyloxytrimethylsilane

Downstream raw materials:

2-methoxy-3-phenyl-7-(trifluoromethyl)isoquinolin-1(2H)-one