20187-61-5

Basic information

• Product Name: Ethanone, 2-[(methylsulfonyl)oxy]-1-phenyl-
• Synonyms: methanesulfonic acid 2-oxo-2-phenylethyl ester;2-phenyl-2-oxoethyl methanesulfonate;2-oxo-2-phenylethyl methanesulfonate
• CAS NO: 20187-61-5
• Molecular Formula: C9H10O4S
• Molecular Weight: 214.242
• Mol File: 20187-61-5.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-[(methylsulfonyl)oxy]-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-[(methylsulfonyl)oxy]-1-phenyl-(20187-61-5)
• EPA Substance Registry System: Ethanone, 2-[(methylsulfonyl)oxy]-1-phenyl-(20187-61-5)

Safety Data

• Hazardous Substances Data: 20187-61-5(Hazardous Substances Data)

Upstream product

• 105551-42-6 (mesyloxyhydroxyiodo)benzene 
• 98-86-2 acetophenone 
• 98-85-1 1-Phenylethanol 
• 75-75-2 methanesulfonic acid 
• 536-80-1 iodosylbenzene 
• 124-63-0 methanesulfonyl chloride 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 109-99-9 tetrahydrofuran 
• 536-74-3 phenylacetylene 
• 65-85-0 benzoic acid 
• 109-52-4 valeric acid 
• 802294-64-0 propionic acid 
• 64-19-7 acetic acid 
• 13735-81-4 1-styrenyloxytrimethylsilane 

Downstream Products

• 343239-88-3 (1R)-2-O-methanesulfonyl-1-phenyl-1,2-ethanediol 
• 20780-54-5 (S)-styrene oxide 
• 5399-30-4 2-oxo-2-phenylethylthiocyanate 
• 88730-73-8 3-Hydroxy-3-(2-oxo-2-phenyl-ethyl)-1,3-dihydro-indol-2-one 

Relevant articles and documents

Gold-catalyzed synthesis of 4-(2-Oxoalkoxy)butyl Methanesulfonates via ring-opening of tetrahydrofuran

A variety of terminal alkynes were converted into the corresponding 4-(2-oxoalkoxy)butyl methanesulfonates via a gold-catalyzed intermolecular oxidation reaction using 8-ethylquinoline N-oxide as the oxidant and THF as the solvent. This reaction is proposed to proceed through the ring-opening of THF via an α-oxo gold carbene intermediate.

Selective Asymmetric Transfer Hydrogenation of α-Substituted Acetophenones with Bifunctional Oxo-Tethered Ruthenium(II) Catalysts

A practical method for the asymmetric transfer hydrogenation of α-substituted ketones was developed utilizing oxo-tethered N-sulfonyldiamine-ruthenium complexes. Reduction by HCO2H and HCO2K in a mixed solvent of EtOAc/H2O allowed for the selective synthesis of halohydrins from 2-bromoacetophenone (98%) and 2-chloroacetophenone (>99%), leading to suppressed undesired side reactions stemming from formylation under the typical reaction conditions using an azeotropic 5:2 mixture of HCO2H and Et3N. A range of functional groups, such as halogens, methoxy, nitro, dimethylamino, and ester groups, were well tolerated, highlighting the potential of this method. Nearly complete selectivity with a preferable ee was maintained even with a substrate/catalyst (S/C) ratio of 5000. This catalyst system was also effective for the asymmetric reduction of α-sulfonated ketones without eroding the leaving group. (Figure presented.).

One-step synthesis of methanesulfonyloxymethyl ketones via gold-catalyzed oxidation of terminal alkynes: A combination of ligand and counter anion enables high efficiency and a one-pot synthesis of 2,4-disubstituted thiazoles

By using Mor-DalPhos as the P,N-bidentate ligand and mesylate as the counter ion, the resulting gold(I) complex catalyzes efficient oxidative transformations of various terminal alkynes into synthetically versatile methanesulfonyloxymethyl ketones. The mild reaction conditions and high efficiency permit the one-pot synthesis of a range of valuable 2,4-disubstituted thiazoles by subjecting the resulting reaction mixture to a further condensation with thioamides under mild conditions.