morpholinobenzyl formamide

Base Information

• Chemical Name: morpholinobenzyl formamide
• CAS No.: 22027-75-4
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 220.271
• Mol file: 22027-75-4.mol

Synonyms:morpholinobenzyl formamide

Chemical Property of morpholinobenzyl formamide

Chemical Property:

Purity/Quality:

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Technology Process of morpholinobenzyl formamide

There total 4 articles about morpholinobenzyl formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

morpholine (110-91-8,99108-56-2) + benzaldehyde (100-52-7) + formamide (77287-34-4,77287-35-5,60100-09-6) → morpholinobenzyl formamide (22027-75-4)

Guidance literature:

In ethanol; for 2.5h;

DOI:10.1080/00397919508015428

Reference yield: 65.0%

1-morpholino[(phenyl)methyl]benzotriazole (120803-36-3) + formamide (77287-34-4,77287-35-5,60100-09-6) → morpholinobenzyl formamide (22027-75-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; 1.) r.t., 1 h, 2.) reflux, 24 h;

DOI:10.1055/s-1998-2164

Reference yield: 62.0%

morpholine (110-91-8,99108-56-2) + 1-(α-formylaminobenzyl)benzotriazole (130291-05-3) → morpholinobenzyl formamide (22027-75-4)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 12h;

DOI:10.1055/s-1993-25788

upstream raw materials:

4,4'-(phenylmethylene)bismorpholine

formamide

morpholine

1-(α-formylaminobenzyl)benzotriazole