120803-36-3

Upstream product

• 110-91-8 morpholine 
• 95-14-7 1,2,3-Benzotriazole 
• 100-52-7 benzaldehyde 
• 121239-02-9 N-<α-(benzotriazol-2-yl)phenylmethyl>morpholine 

Downstream Products

• 143008-07-5 1-[(2R,3R)-3-((R)-Morpholin-4-yl-phenyl-methyl)-tetrahydro-furan-2-yl]-1H-benzotriazole 
• 143008-07-5 1-[(2S,3R)-3-((R)-Morpholin-4-yl-phenyl-methyl)-tetrahydro-furan-2-yl]-1H-benzotriazole 
• 143008-07-5 1-[(2R,3S)-3-((R)-Morpholin-4-yl-phenyl-methyl)-tetrahydro-furan-2-yl]-1H-benzotriazole 
• 143008-07-5 1-[(2S,3S)-3-((R)-Morpholin-4-yl-phenyl-methyl)-tetrahydro-furan-2-yl]-1H-benzotriazole 
• 111097-39-3 4-(1-phenylpentyl)morpholine 
• 130473-99-3 1-(Morpholin-4-yl-phenyl-methyl)-cyclohexanecarboxylic acid ethyl ester 
• 126200-32-6 ethyl 2-((1H-benzo[d][1,2,3]triazol-1-yl)(phenyl)methyl)-3-oxobutanoate 
• 51643-92-6 4-(phenyl-phenylsulfanyl-methyl)-morpholine 
• 94-41-7 benzalacetophenone 
• 114460-92-3 1,3-diphenyl-3-morpholino-1-propyne 
• 134005-05-3 3-((1H-benzo[d][1,2,3]triazol-1-yl)(phenyl)methyl)pentane-2,4-dione 
• 22027-65-2 N-[1-morpholino(benzyl)] benzamide 
• 22027-75-4 morpholinobenzyl formamide 

Relevant academic research and scientific papers

Classical benzotriazole-mediated α-aminoalkylations of alkynes: Synthesis and characterization of alk-2-yn-1-amines as amphiphilic materials

Reactions of readily available and stable benzotriazolemethanamines 1a-1, obtained from aldehydes and secondary amines (Scheme 2), gave the expected alk-2-yn-1-amines 3a-t (Scheme 3). The amphiphilic character of the synthesized products was responsible f

THE CHEMISTRY OF N-SUBSTITUTED BENZOTRIAZOLES. PART 18. A STUDY OF THE INFLUENCE OF STRUCTURE ON THE 1- TO 2-(N,N-DIALKYLAMINOALKYL)BENZOTRIAZOLE EQUILIBRIUM

The equilibrium constants, the associated free energies for the equilibria, and the free energies of activation for the isomerization process of a series of 1- and 2-(N,N-dialkylaminoalkyl)benzotriazoles of types (8)-(11) were calculated from the variable temperature 1H-nmr spectra.Trends in the magnitudes of these energies and equilibrium constants are correlated with the molecular structure.

The Chemistry of N-Substituted Benzotriazoles. Part 14. Novel Routes to Secondary and Tertiary Amines and to N,N-Disubstituted Hydroxylamines

Tertiary amines of types R4R3CHNR1R2 (2), (R2CH2)2NR1 (10) and 11, or (R2CH2)3N (12), secondary amines of type (R2CH2)2NH (8), and N,N-disubstituted hydroxylamines of type (R2CH2)2NOH (9), are prepared in high yield by the action of Grignard reagents or sodium borohydride on easily available N,N-dialkyl-N-amines (1) or tris(benzotriazolylmethyl)amine (7), on bis(benzotriazolylmethyl)amines (3), (5), and (6), and on N,N-bis(benzotriazolylmethyl)hydroxylamine (4), respectively.

A New General Method for the Synthesis of Tertiary Propargylamines (N,N-Dialkyl-2-alkynamines)

A new method has been developed for the preparation of propargylamines, compounds of pharmaceutical interest.The method employs mild conditions, affords good overall yields, and is succesfully applied even in cases where other methods fail.