(1'S,2'S)-(2'-azido-cyclohexyl)oxy-aceticacid-(2,2)-dimethylpropionicacid anhydride

Base Information

Chemical Name:(1'S,2'S)-(2'-azido-cyclohexyl)oxy-aceticacid-(2,2)-dimethylpropionicacid anhydride
CAS No.:777939-57-8
Molecular Formula:C₁₃H₂₁N₃O₄
Molecular Weight:283.327
Hs Code.:

Synonyms:(1'S,2'S)-(2'-azido-cyclohexyl)oxy-aceticacid-(2,2)-dimethylpropionicacid anhydride

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Chemical Property of (1'S,2'S)-(2'-azido-cyclohexyl)oxy-aceticacid-(2,2)-dimethylpropionicacid anhydride

Chemical Property:

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Technology Process of (1'S,2'S)-(2'-azido-cyclohexyl)oxy-aceticacid-(2,2)-dimethylpropionicacid anhydride

There total 2 articles about (1'S,2'S)-(2'-azido-cyclohexyl)oxy-aceticacid-(2,2)-dimethylpropionicacid anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3282-30-2
pivaloyl chloride

: 357922-50-0
(1'S,2'S)-(2'-azido-cyclohexyl)oxy-acetic-acid-tert-butylester

: 777939-57-8
(1'S,2'S)-(2'-azido-cyclohexyl)oxy-aceticacid-(2,2)-dimethylpropionicacid anhydride

Guidance literature:: (1'S,2'S)-(2'-azido-cyclohexyl)oxy-acetic-acid-tert-butylester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

pivaloyl chloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.1021/ol048861q

Reference yield:

: 286-20-4
cyclohexene oxide

: 777939-57-8
(1'S,2'S)-(2'-azido-cyclohexyl)oxy-aceticacid-(2,2)-dimethylpropionicacid anhydride

Guidance literature:: Multi-step reaction with 2 steps

1.1: (R,R)-Salen-CrN₃ / diethyl ether; propan-2-ol / 36 h / 4 °C

1.2: TFA / methanol / 1 h / 20 °C

1.3: 95 percent / tetrabutylammonium bromide; aq. NaOH / toluene / 18 h / 20 °C

2.1: TFA / CH₂Cl₂ / 1.5 h / 20 °C

2.2: DIEA / dimethylformamide / 1 h / 0 °C

With (R,R)-Salen-CrN₃; trifluoroacetic acid; In diethyl ether; dichloromethane; isopropyl alcohol;
DOI:10.1021/ol048861q

Reference yield: 91.0%

: 777939-57-8
(1'S,2'S)-(2'-azido-cyclohexyl)oxy-aceticacid-(2,2)-dimethylpropionicacid anhydride

: 357922-53-3
{(1S,2S)-2-[2-((1S,2S)-2-Azido-cyclohexyloxy)-acetylamino]-cyclohexyloxy}-acetic acid tert-butyl ester

: 777939-58-9
[(1S,2S)-2-(2-{(1S,2S)-2-[2-((1S,2S)-2-Azido-cyclohexyloxy)-acetylamino]-cyclohexyloxy}-acetylamino)-cyclohexyloxy]-acetic acid tert-butyl ester

Guidance literature:: {(1S,2S)-2-[2-((1S,2S)-2-Azido-cyclohexyloxy)-acetylamino]-cyclohexyloxy}-acetic acid tert-butyl ester; With hydrogen; palladium on activated charcoal; In methanol;

(1'S,2'S)-(2'-azido-cyclohexyl)oxy-aceticacid-(2",2")-dimethylpropionicacid anhydride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 6h;
DOI:10.1021/ol048861q