N-methoxy-3,3-diphenylacrylamide

Base Information

• Chemical Name: N-methoxy-3,3-diphenylacrylamide
• CAS No.: 1072809-99-4
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.301
• Mol file: 1072809-99-4.mol

Synonyms:N-methoxy-3,3-diphenylacrylamide

Chemical Property of N-methoxy-3,3-diphenylacrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-methoxy-3,3-diphenylacrylamide

There total 11 articles about N-methoxy-3,3-diphenylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3,3-diphenylacrylic acid (606-84-8) + N-methoxylamine hydrochloride (593-56-6) → N-methoxy-3,3-diphenylacrylamide (1072809-99-4)

Guidance literature:

3,3-diphenylacrylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.25h;

N-methoxylamine hydrochloride; With 4-methyl-morpholine; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.1002/adsc.201900530

Reference yield: 64.0%

(E)-N-methoxy-3-phenyl-2-propenamide (112404-04-3) + phenylboronic acid (98-80-6) → N-methoxy-3,3-diphenylacrylamide (1072809-99-4) + 1-methoxy-4-phenylquinolin-2(1H)-one (1072810-17-3)

Guidance literature:

With 1,10-Phenanthroline; copper (II) trifluoroacetate hydrate; palladium diacetate; silver(l) oxide; In acetic acid; at 100 ℃; Inert atmosphere;

DOI:10.1039/c2cc30600j

Reference yield: 16.0%

(E)-N-methoxy-3-phenyl-2-propenamide (112404-04-3) + phenylboronic acid (98-80-6) → 3,3-diphenylacrylamide (4439-11-6) + N-methoxy-3,3-diphenylacrylamide (1072809-99-4) + cinnamamide (621-79-4,22031-64-7)

Guidance literature:

With 1,10-Phenanthroline; palladium diacetate; In acetic acid; at 100 ℃; Inert atmosphere;

DOI:10.1039/c2cc30600j

upstream raw materials:

3,3-diphenylacryloyl chloride

N-methoxylamine hydrochloride

(E)-3-phenylacrylic acid

(E)-N-methoxy-3-phenyl-2-propenamide

Downstream raw materials:

1-methoxy-4-phenylquinolin-2(1H)-one