(2R,4R)-4-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluoro-2-hydroxybutyl benzoate

Base Information

Chemical Name:(2R,4R)-4-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluoro-2-hydroxybutyl benzoate
CAS No.:634181-81-0
Molecular Formula:C₂₃H₂₆F₂O₆
Molecular Weight:436.453
Hs Code.:

Synonyms:(2R,4R)-4-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluoro-2-hydroxybutyl benzoate

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Chemical Property of (2R,4R)-4-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluoro-2-hydroxybutyl benzoate

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Technology Process of (2R,4R)-4-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluoro-2-hydroxybutyl benzoate

There total 6 articles about (2R,4R)-4-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluoro-2-hydroxybutyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 98-88-4
benzoyl chloride

: 634181-79-6
(2R,4R)-4-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluorobutane-1,2-diol

: 634181-81-0
(2R,4R)-4-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluoro-2-hydroxybutyl benzoate

Guidance literature:: With pyridine; In dichloromethane; at -70 ℃; for 2h;
DOI:10.1021/jo034512i

Reference yield:

: 634181-78-5
(R)-4-((R)-1-(benzyloxy)-2,2-difluorobut-3-en-1-yl)-2,2-dimethyl-1,3-dioxolane

: 634181-81-0
(2R,4R)-4-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluoro-2-hydroxybutyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 47.5 percent / OsO₄; NMNO; H₂O / acetone / 48 h / 20 °C

2: 90 percent / pyridine / CH₂Cl₂ / 2 h / -70 °C

With pyridine; osmium(VIII) oxide; bis-(2-chloro-ethyl)-methyl-amine oxide; water; In dichloromethane; acetone;
DOI:10.1021/jo034512i

Reference yield:

: 100-39-0
benzyl bromide

: 634181-81-0
(2R,4R)-4-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluoro-2-hydroxybutyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: NaH; Bu₄NI / tetrahydrofuran / 0 - 20 °C

2: 47.5 percent / OsO₄; NMNO; H₂O / acetone / 48 h / 20 °C

3: 90 percent / pyridine / CH₂Cl₂ / 2 h / -70 °C

With pyridine; osmium(VIII) oxide; bis-(2-chloro-ethyl)-methyl-amine oxide; water; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jo034512i