5-bromo-2-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-pyridine

Base Information

• Chemical Name: 5-bromo-2-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-pyridine
• CAS No.: 1309959-26-9
• Molecular Formula: C₁₆H₁₀BrCl₂F₃N₂O
• Molecular Weight: 454.073
• Mol file: 1309959-26-9.mol

Synonyms:5-bromo-2-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-pyridine

Chemical Property of 5-bromo-2-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-2-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-pyridine

There total 6 articles about 5-bromo-2-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (864725-22-4) + 5-bromo-4-methyl-pyridine-2-carbaldehyde oxime (1309959-25-8) → 5-bromo-2-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-pyridine (1309959-26-9)

Guidance literature:

5-bromo-4-methyl-pyridine-2-carbaldehyde oxime; With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

1-(5-bromo-4-methyl-2-pyridyl)ethanone (1413285-68-3) + 3,5-dichloro-2,2,2-trifluoroacetophenone (130336-16-2) → 5-bromo-2-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-pyridine (1309959-26-9)

Guidance literature:

1-(5-bromo-4-methyl-2-pyridyl)ethanone; 3,5-dichloro-2,2,2-trifluoroacetophenone; With potassium carbonate; triethylamine; In 1,2-dichloro-ethane; for 20h; Reflux;

With hydroxylamine hydrochloride; tetrabutylammomium bromide; sodium hydroxide; In water; 1,2-dichloro-ethane; at 0 - 20 ℃; for 16h;

Reference yield:

5-bromo-2-iodo-4-methylpyridine (941294-57-1) → 5-bromo-2-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-pyridine (1309959-26-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 1 h / -15 - -10 °C

1.2: 1 h / -15 - 0 °C

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 0.25 h / 20 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; isopropylmagnesium bromide; sodium acetate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

2,5-Dibromo-4-methylpyridine

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

5-bromo-4-methyl-pyridine-2-carbaldehyde oxime

5-bromo-4-methylpyridine-2-carbaldehyde

Downstream raw materials:

C₂₁H₁₉Cl₂F₃N₂O₃

6-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-nicotinic acid

ethyl 2-[[6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-4-methyl-3-pyridyl]sulfanyl]acetate

2-[[6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-4-methyl-3-pyridyl]sulfanyl]acetic acid